MIN-117

MIN-117
Identifiers
	IUPAC name (2S)-1-[4-(3,4-Dichlorophenyl)piperidin-1-yl]-3-[2-(5-methyl-1,3,4-oxadiazol-2-yl)benzo[b]furan-4-yloxy]propan-2-ol;
ChemSpider	7981825;
Chemical and physical data
Formula	C25H25Cl2N3O
Molar mass	454.40 g·mol−1
3D model (Jmol)	Interactive image;
	SMILES Clc1ccc(cc1Cl)C2CCN(CC2)C[C@H](O)COc4cccc3oc(cc34)c5nnc(o5)C ;
	InChI InChI=1S/C25H25Cl2N3O4/c1-15-28-29-25(33-15)24-12-19-22(3-2-4-23(19)34-24)32-14-18(31)13-30-9-7-16(8-10-30)17-5-6-20(26)21(27)11-17/h2-6,11-12,16,18,31H,7-10,13-14H2,1H3/t18-/m0/s1 ; Key:XIYDIPLATGRHEC-SFHVURJKSA-N ;

MIN-117 (known formerly as WF-516) is an investigational antidepressant which is under development by Minerva Neurosciences for the clinical treatment of major depressive disorder (MDD).^[2]^[3]^[4] It is described as a 5-HT_1A and 5-HT_2A receptor antagonist and inhibitor of serotonin and dopamine reuptake,^[4]^[5]^[6] and is also reported to possess affinity for the α_1A- and α_1B-adrenergic receptors.^[4]^[6] As of May 2015, MIN-117 is in phase II clinical trials for MDD.^[3]

References[edit]

^ Kato, Tadafumi; Saijo, Takeaki; Maeda, Jun; Okauchi, Takashi; Maeda, Jun-ichi; Morio, Yasunori; Kuwahara, Yasuhiro; Suzuki, Masayuki; Goto, Nobuharu; Fukumura, Toshimitsu; Suhara, Tetsuya; Higuchi, Makoto (2012). "Presynaptic Selectivity of a Ligand for Serotonin 1A Receptors Revealed by In Vivo PET Assays of Rat Brain". PLoS ONE. 7 (8): e42589. doi:10.1371/journal.pone.0042589. ISSN 1932-6203. PMC 3413639. PMID 22880045.
^ "Minerva Neuroscience". Retrieved 2015-05-19.
^ ^a ^b Minerva Neurosciences (2015). "Minerva Neurosciences Reports First Quarter 2015 Financial Results and Other Key Business Updates". GlobalNewswire. Retrieved 2015-05-19.
^ ^a ^b ^c Minerva Neurosciences. "Investor Presentation March 2015" (PDF). Retrieved 2015-05-19.
^ "Company Profile for Minerva Neurosciences Inc.". Reuters. Retrieved 2015-05-19.
^ ^a ^b Don Dion (2014). "Some Nerves Surrounding Minerva Neurosciences IPO". Seeking Alpha. Retrieved 2015-05-19.

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Identifiers

IUPAC name (2S)-1-[4-(3,4-Dichlorophenyl)piperidin-1-yl]-3-[2-(5-methyl-1,3,4-oxadiazol-2-yl)benzo[b]furan-4-yloxy]propan-2-ol^[1]
ChemSpider	7981825
Chemical and physical data
Formula	C₂₅H₂₅Cl₂N₃O
Molar mass	454.40 g·mol⁻¹
3D model (Jmol)	Interactive image
SMILES Clc1ccc(cc1Cl)C2CCN(CC2)C[C@H](O)COc4cccc3oc(cc34)c5nnc(o5)C
InChI InChI=1S/C25H25Cl2N3O4/c1-15-28-29-25(33-15)24-12-19-22(3-2-4-23(19)34-24)32-14-18(31)13-30-9-7-16(8-10-30)17-5-6-20(26)21(27)11-17/h2-6,11-12,16,18,31H,7-10,13-14H2,1H3/t18-/m0/s1 Key:XIYDIPLATGRHEC-SFHVURJKSA-N