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Science AMA Series: I'm Dr Helen Webberley, I am a gender specialist and I offer support, advice and treatment to gender variant people, via my online clinic GenderGP. AMA! by Dr_Helen_WebberleyNHS GP | Sexual Health in science

[–]this-is-the-future 10 points11 points  (0 children)

You are being disingenuous. The chromosomal genital mismatch that you are talking about is a very severe condition that could lead to death depending on the situation. In other words it is abnormal and not a good match with the transgender debate.

Edit: Being transgender has nothing to do with the "there are more than two biological genders" argument being presented so I can only deduce that this is more of a sociological handwaving than a true analysis of the science. Whenever somebody tries do discredit the reality of biological gender they are typically coming from a point of view that has little interest in actual science and is more aligned with sociology.

Science AMA Series: I'm Dr Helen Webberley, I am a gender specialist and I offer support, advice and treatment to gender variant people, via my online clinic GenderGP. AMA! by Dr_Helen_WebberleyNHS GP | Sexual Health in science

[–]Bardfinn 164 points165 points  (0 children)

This question makes it seem as if the only person involved in making the decision to transition, is the patient.

It is the equivalent of

"Also, what is the justification for those in the medical profession to allow people without a fully developed frontal cortex to consent to [chemotherapy for cancer|donating a kidney|donating bone marrow|having their appendix removed]".

All these are procedures that drastically alter their bodies in permanent ways.

The justification for transition therapies is the same justification for any other therapy: there is research supporting a reasonably foreseeable outcome of the therapy treating a syndrome.

The justification for not allowing ideologues to legislate / dictate / politicise transition / gender medical science is the same justification for not allowing ideologues to legislate / dictate / politicise blood transfusions, and organ donations, and surgery itself: the patient owns their body and the ideologues are, absent specific legal guardianship, legally disinterested third parties who are not allowed to dictate medical treatment.

To sum up: the justification is because science has demonstrated a therapeutic effect from the therapy that far outweighs side effects.

Earth's oceans are warming 13% faster than thought, and accelerating by loremipsumchecksum in science

[–]Thanks-For_The-Gold 724 points725 points  (0 children)

Also, with regards to coral and acid, coral is basically made from calcium. Calcium neutralizes acid, but that reaction binds the calcium to the acid and takes it away from the structure it was part of. So basically, acidity eats away at the coral, slowly killing and dissolving it, as well as taking away the calcium in surrounding areas that it needs to grow. (A similar thing happens to buildings made from limestone and such, acid rain erodes it much faster and many historical buildings risk destruction due to this).

But the acidity is also dangerous to other species. Coral is the most vulnerable, and that's part of why coral's suffering so much today. But other species also need calcium for their bones and teeth, and especially their shells. Acidification of the water softens these body parts since they aren't as calcified anymore, and they're thus more fragile. Without a proper shell to protect themselves or teeth to eat, these species suffer too.

Additionally, aquatic life is very sensitive to both pH levels and temperature. If you've ever had a fish tank, you'll recall having to constantly monitor the pH and temperature or else your fish would die (unless they were very hardy fish like zebra fish or maybe guppies). This is partly because what seems like a small change in pH, like 8.2 to 8.1, is really about a 25% increase in the concentration of acidity.

So while it may seem like CO2 isn't a big deal and it will have minimal effect on us, the effect on the oceans is potentially more serious than most people believe and if we lose ocean life it will directly affect our atmosphere and our food supply.

Are the oceans going to totally die out in a few years? Almost certainly not. We can take our time somewhat as we switch to renewable fuels or other less emissive sources, like we're currently doing, and we might manage to save everything except perhaps for lots of coral and some other species. That's probably ultimately better than the huge costs and instability of shutting down every power plant tomorrow. But we should be working towards reducing emissions, as the oceans are slow to change and even if we totally stopped CO2 emissions today their effects would continue to change the ocean for some time - so we need to ensure that we stop before our momentum would carry us over the breaking point regardless.

Feeling authentic in a relationship comes from being able to be your best self, not your actual self by HeinieKaboobler in science

[–]ElMelonTerrible 875 points876 points  (0 children)

Most of what we do every day is performed with little attention and no special effort, because attention and effort are scarce resources. Your "actual self" is how you act when you can't afford a special effort. Your "best self" is how you can perform when you make an extra effort to improve on the behavior that comes naturally. If your efforts are consistently rewarded, this pattern of reward reprograms your brain, and your "actual self" becomes more like your "best self." The best relationships are the ones where this process works most smoothly to help you improve your "actual self."

For example, in work relationships, there is a level of performance that comes easily and naturally, and there is a higher level of performance that you have to stretch to achieve. The best kind of boss or coworker is one who appreciates your efforts to perform better and recognizes and respects better performance when you achieve it. If your boss can't tell the difference between poor performance and good performance, or your coworkers resent your efforts to perform better, then those relationships aren't good for you, because they make it very hard to improve.

In intimate relationships, perhaps your current "actual self" is one who shirks housework and gets angry when your partner points it out. Your "best self" is when you make a special effort to do your share of the housework and take criticism over housework naturally. A good relationship is one where your partner reinforces your efforts with positive feedback. A bad relationship would be one where your partner criticizes you just as harshly, or even more harshly, when you invest effort in improving your behavior.

I suspect the feeling of authenticity comes from feeling free to let your aspirations and efforts be visible to other people, instead of having to hide them.

Transgender and gender-fluid teens, particularly those assigned male at birth, face up to 3 times more mental and physical abuse at school and at home than their gender-conforming peers, raising their risk of depression, post-traumatic stress, self-harm, and suicide. by drewiepoodle in science

[–]drewiepoodle[S] 5 points6 points  (0 children)

Actually, the depression, self harm, and suicide attempts all decrease after a successful transition.

A study found that a clinical protocol of a multidisciplinary team with mental health professionals, physicians, and surgeons, including puberty suppression, followed by cross-sex hormones and gender reassignment surgery, provides gender dysphoric youth who seek gender reassignment from early puberty on, the opportunity to develop into well-functioning young adults.

Pausing Puberty with Hormone Blockers May Help Transgender Kids

Another study shows that socially transitioned transgender children who are supported in their gender identity have developmentally normative levels of depression and only minimal elevations in anxiety, suggesting that psychopathology is not inevitable within this group. Especially striking is the comparison with reports of children with GID; socially transitioned transgender children have notably lower rates of internalizing psychopathology than previously reported among children with GID living as their natal sex.

A recent study showed that transgender children who socially transition early are comparable to cis-gender children in measures of mental health.

Furthermore, a study with 32 transgender children, ages 5 to 12, indicates that the gender identity of these children is deeply held and is not the result of confusion about gender identity or pretense. The study is one of the first to explore gender identity in transgender children using implicit measures that operate outside conscious awareness and are, therefore, less susceptible to modification than self-report measures.

A new study has revealed that it's general exchanges of words and signs of affection following sex that directly cause increased long-term happiness and more life satisfaction in couples who have sex at least once a week. by Wagamaga in science

[–]KCG0005 3730 points3731 points  (0 children)

Counter-point: individuals in good relationships are self-aware enough to know that, even when they don't feel like it, a show of affection after sex deepens the bond between them, so they make determined efforts to show that their appreciation is for more than the sex itself.

A new study has revealed that it's general exchanges of words and signs of affection following sex that directly cause increased long-term happiness and more life satisfaction in couples who have sex at least once a week. by Wagamaga in science

[–]johnkalos66 8688 points8689 points  (0 children)

It seems like couples that are exchanging kind words and showing affection generally already have a good relationship to be doing that. It seems correlated but I'm not sure about directly caused..

Scientists discovered that brain cells prefer one parent's genes over the other's which defies classic genetics and suggests new ways that genetic mutations might cause brain disorders by rawbamaticBS|Mathematics in science

[–]RollingInTheD 238 points239 points  (0 children)

Imagine being the researcher sitting up in the lab, late at night, waiting for your mass spec to spit out the composition of a particular protein found in a particular organelle of a particular bacteria, and accidentally stumbling across a coding comment from a higher power that just reads;

"Important line - do not delete again. Frank, if I have to come down there and reinsert this one more time, you're off the Earth project entirely"

Scientists discovered that brain cells prefer one parent's genes over the other's which defies classic genetics and suggests new ways that genetic mutations might cause brain disorders by rawbamaticBS|Mathematics in science

[–]Snackleton 1004 points1005 points  (0 children)

What this article is missing is a mention of genomic imprinting, which is a process that happens during fetal development.

To summarize the concept: The expression of your parents genes are in conflict, each having their own selfish interests. Your mother's genes would "prefer" that the fetus consume fewer maternal resources and have an earlier birth. Paternal genes would prefer a longer gestational period and higher consumption of maternal resources, so that the child is healthier, or better "provisioned" when born.

If paternal imprinting is too strong, the mother may have gestational diabetes or preeclampsia, but birth weight will be higher. If maternal imprinting is too strong, the mother may not have experienced a difficult pregnancy, but premature birth can occur.

There are also mental disorders associated with imprinting that's too strong (check out the Crespi-Badcock hypothesis).

Edit: Thanks for the gold, stranger! Since I'm just an evolutionary biologist and not a human geneticist, I'll point people in the direction of a comment from /u/RighteousVillain which offers some additional detail:

What you described is actually one of the theories about WHY imprinting exists and not what it actually is. Imprinting itself is the marking of specific genes during development, or actually during the maturation of germ cells before fertilization, that results in differential expression based on inheritance from the mother or father. The concept you supplied, and very well said btw, is often referred to as the conflict theory and has the most evidence for it in my opinion. Especially considering the large number of imprinted genes and clusters that are found in the placenta. Another popular theory is called the ovarian time bomb hypothesis (if I recall correctly) and it states that imprinting exists to prevent parthenogenetic offspring (meaning offspring developing from an unfertilized egg). This is beneficial because parthenogenetic offspring would not have recombination of maternal and paternal DNA which can be evolutionarily advantageous. Also, haploid eggs spontaneously arising can result in ovarian cancer (time bomb) that is defused by imprinted genes. I believe there are other theories, but these 2 appear to be the best supported. Source: I recently earned my Ph.D. while researching the mechanisms of the Angelman syndrome imprinting center and its role at the Prader-Willi/Angelman syndrome locus.

Edit 2: Carl Zimmer does a great job of explaining the conflict theory of pregnancy in this article.

The pancreas can be triggered to regenerate itself through a type of fasting diet, say US researchers. Restoring the function of the organ - which helps control blood sugar levels - reversed symptoms of diabetes in animal experiments. by NinjaDiscoJesus in science

[–]giltwistPhD | Curriculum and Instruction | Math 2661 points2662 points  (0 children)

People spend five days on a low calorie, low protein, low carbohydrate but high unsaturated-fat diet.

Had to dig a little bit but here is the actual diet.

To save you a click:

  • Broth
  • Extra virgin olive oil
  • Vegetable powder (Beat, collard, kale, carrot, nettle, tomato, mushroom)

The article also refers to a meal plan called Prolon which has olives, lentils, tea, and some almond bars. An avocado might also be in the nutritional ballpark of a handful of olives.

A study from a team of US researchers suggests that a combination of genital stimulation, deep kissing and oral sex is the “golden trio” for women when it comes to increasing their likelihood of reaching orgasm with a sexual partner. by Wagamaga in science

[–]bxa121 38 points39 points  (0 children)

It's a science sub Reddit. Your comments must contain relevant scientific contributions. It's all in the wiki

Edit: my sincere and humble thanks for the gold kind stranger

Top students more likely to smoke pot, drink alcohol, study says by ADONBILIVITT in science

[–]thaways1 44 points45 points  (0 children)

He might not be homeless if the cost of getting high wasn't an issue for him.

A new study suggests that the spinal cord determines if we are left- or right-handed by Kooby2 in science

[–]BaldEagleBomber 91 points92 points  (0 children)

Read the article he linked. It's not at all about logic and creative. It's about language development.

The scientists found a strong link between a variant of a gene called PCSK6 and relative hand skill in these children with reading difficulties. Specifically, while most people are better at using their right hand, those who carried the variant in PCSK6 were, on average, more skilled with their right hand compared to the left than those not carrying the variant. This result was also seen in two independent groups of children with reading difficulties.

The protein product of the gene PCSK6 is known to interact with another protein called NODAL. Previous experiments have shown that NODAL plays a key role in establishing left-right asymmetry early in embryonic development. This suggests that genetic variants of PCSK6 may have an effect on the initial left-right patterning of the embryo that in turn influences the development of brain asymmetry, and thus handedness.

Furthermore, as William Brandler, one of the study's authors explains: "Our closest relatives, the great apes, do not display the striking bias towards right-handedness seen in humans. So understanding the genetic basis of handedness may offer us significant insights into our evolution."

More specifically on handedness being linked to which brain hemisphere develops fastest, it's not about logic or creative, it's about Broca's area and Wernicke's area, sometimes called the language center, developing faster than our motor skills. Broca's area and Wernicke's area are in the left side of the brain, thereby giving rise to right handedness.

The more depressed your romantic partner may be, the more love you should give them, according to new University of Alberta research. The study, published in Developmental Psychology, surveyed 1,407 couples on their levels of depression, self-esteem and mutual support. by mveaMD-PhD-MBA | Clinical Professor/Medicine in science

[–]pixel_fortune 282 points283 points  (0 children)

You can be a depressed person in a relationship, but you're correct that you can't give her the burden of making you happy. That's for you (and a therapist). She can support you but she can't cure you. But you're allowed a partner, really you are.

Harsh parenting can lead to poor school outcomes by making teenagers seek immediate rewards and prioritize relationships with their friends over responsibilities. by prodigies2016 in science

[–]YeastInVagMakesBread 2894 points2895 points  (0 children)

Not a psychologist, but I feel as though this study didn't focus on the emotional aspect of the kids attachments to their peer groups. The kids don't get the warmth, love, and attention from their parents, so when they get it from their peers, they go to extremes to chase those positive feelings from others.

Amazonian rainforests once thought to be pristine wildernesses are increasingly known to have been inhabited by large populations before European contact. Prior to anthropogenic forest that had been actively managed for millennia, bamboo forest dominated the region for ≥6,000 years. by avogadros_number in science

[–]MictlantecuhtliGrad Student | Anthropology | Mesoamerican Archaeology 46 points47 points  (0 children)

For the sake of scale/context, how big is that dome on the left

The dome measures about 37.5m in diameter, 8m in total height. The entire structure, from platform to platform, measures approximately 99m. This circular arrangement of platforms around a patio space and central structure we call an altar is called a guachimonton.

The naming can get confusing. The site in the picture above is called Los Guachimontones and is named after a district in the town this site is located near. Each individual structure, however, is called a guachimonton. The town is called Teuchitlan and we named the culture who built these structures the Teuchitlan culture.

At Los Guachimontones there are eight guachimontones and two ballcourts. There is a sister site located further up the hill with five guachimontones and one ballcourt. The immediate area of these two sites makes this the largest site in the Tequila valleys.

There are about 50 or so guachimontones in the Tequila valleys with one in the Bolaños canyon to the north, one by Puerto Vallarta, one by the town of Comala in Colima, one in the western area of the Atemajac Valley (where Guadalajara is), and several in Guanajuato to the east. There's supposedly one in Nayarit and another at La Campana in Colima, though I've never seen pictures or drawings of it.

Speculatively, why is this not discussed or researched? Funding? Interest? Not sexy enough?

Jalisco, Nayarit, and Colima are known more for their large and small, hollow and solid ceramic figures and dioramas that are attributed to the shaft and chamber tombs the dead were buried in at that time. Gong as far back as the Early Formative (1500 BC to 800 BC), the people in this widespread region buried their dead in these shaft and chamber tombs. The earliest ones are located at El Opeño in Michoacan by Lake Chapala. This cemetery consisted of simple chambers dug into the ground with a short staircase to reach them. The chamber would be sealed off and the staircase back filled. The tradition continued through the Middle Formative (800 BC to 300 BC) in places like Mascota, Jalisco with simple chambers and simple vertical shafts to reach those chambers. It wasn't until the Late Formative and Early Classic periods (300 BC to 550 AD) that shaft and chamber tombs became more numerous and more elaborate. El Arenal is the largest tomb known to date and was 17m underground with three well carved chambers dug into the soil for the dead. Unfortunately, the tomb was partially looted before Corona Nuñez and a few later Stanley Long were able to document it.

Because these tombs are underground and have little to no surface indicators, almost all of the thousands of ceramic figures in museums across the globe were looted. A lot of this looting was opportunistic in which a farmer finds a depression in his field, digs down a couple of meters, robs the tomb, and sells it to someone in the city who then sells it to museums or art collectors. Some looters made it their job to go around and find these tombs using long metal bars to punch into the ground to try and find a chamber. This looting, however, is not new and has been occurring since the late 1800s. So, too, has the creation of fake ceramic figures been an industry/occupation in this region which casts doubt in the authenticity of the figures in museums today.

Because of this looting, the volume of figures, and the fact that guachimontones are not spectacularly large like pyramids in eastern Mexico or even the yacatas in Michoacan, no one really bothered to take a look any surface architectural remains. Adela Breton was the first one to document these guachimontones in a letter to a friend. While she published the photo of the mound being looted (possibly an altar from a guachimonton) as well as photos and watercolors of the figures recovered from the mound, she never published her sketches of the site. As a result, the most anyone really did when documenting surface architecture was note that there were mounds. If you look at that first picture in the El Arenal album, you can see the arrangement of an altar and platforms that is typical of a guachimonton. But no one recognized it as such. It wasn't until the 1970s that Phil Weigand and his wife noticed these things for what they were when they saw the guachimontones near the town of Ahualulco. Weigand and his wife did some amazing work from the 70s to the 90s doing a lot of small scale survey work, site map drawing, photos, surface finds, etc., but a lot of their work has remained unpublished or published in obscure sources. I had heard that Phil was ridiculed by colleagues who studied other parts of Mesoamerica saying he didn't find anything or that it wasn't important, which drove him towards publishing in obscure places or not publishing at all. He's been vindicated and was able to procure the funds to restore the Los Guachimontones site, but he did not live long enough to see the study of these structures really take off. Phil passed away in 2011 and the study of guachimontones is still trying to take off.

I was drawn to this area because of the unique structures. I thought about continuing with Maya studies in my undergrad until I learned more about the Tarascans in Michoacan. They were so different from the Aztecs and I thought that was intriguing. But then I learned about the Teuchitlan culture and was blown away by how different they were from everyone else. So part of the lack of investigation is interest. Another part has to do with colonial history.

When the Spanish arrived in the Jalisco region, Nahuatl speakers had invaded and completely changed the region. We can pinpoint this at the end the 500s/early 600s when drought gripped the region. This same drought effected Teotihuacan and most likely drove Nahuatl speakers out of marginal areas on the border of Mesoamerica that could not continue to support agriculture. Areas like Zacatecas or Guanajuato. These people fled southward and created a ripple effect. Those that stayed behind just created more people for later migrations in Mesoamerica at the start of the Early Postclassic and Late Postclassic. The Aztecs were the third wave of migrants that occurred at the beginning of the Late Postclassic. Many of the people in the Basin of Mexico when the Aztecs arrived were second wave migrants. And the Toltecs (and maybe the Pipil of El Salvador) appear to be first wave migrants.

But because of the drought and the influx of these migrants in Jalisco, the people stopped building guachimontones. They stopped burying their dead in shaft and chamber tombs. They stopped making ceramic figures in earlier period styles. Instead they adopted the more typical Mesoamerican monumental architecture with stepped platforms. They buried their dead in pits or box-shaped tombs. They brought in other art styles for ceramics, figures, etc. It was a complete change to the point where Epiclassic and Postclassic sites were built away from Late Formative and Classic period sites. You don't see sites with a long chronology going back from 1492 to 300 BC. You see sites that are either 1492 to 550 AD or 550 AD to 300 BC+. There's some kind of breakdown in which the people in the area were either all wiped out (unlikely) or completely rejected everything about their culture in favor of this new culture without ever revisiting their old one (loss of faith?).

When the Spanish arrived they arrived to a region made up of tiny city-states with multiple languages and multiple cultures. Sometimes these languages/cultures coexisted within one area and other times there were fierce rivalries between two neighboring towns. But because there was no large empire or state it was hard for the Spanish to control the region. The Spanish were frustrated because they wanted riches and these people did not produce riches in sufficient quantities like the Aztecs or Tarascans. So many of the Spanish resorted to legal and illegal slaving and sold many people off in the slave markets of Mexico City. Eventually a number of these groups set aside their differences, banded together, and rebelled. They used the Spaniard's own unawareness of cultures and languages to openly organize so that when they rebelled, they rebelled as one. This became the Mixton War of 1540 to 1541. Ida Altman has a great book on this topic. Tragically the early and successful resistance of the Natives was broken by the Spanish. And as punishment the Spanish killed many people, enslaved many more, and decimated the culture and language of these people. So we don't have things like the Florentine Codex or Relacion de Michoacan to turn to because the Spanish never bothered to document all the groups in this area as well. And when people wanted to document the cultures and languages of the past, the cultures and languages had either disappeared, were replaced with Spanish culture, or was culture brought by Aztecs, Tarascans, and Tlaxcallans that were made to settle in this now emptied region of the country.

So with not much in the way of Postclassic/contact sites to study, no pre-hispanic writing to turn to, sites that didn't fit the norm for the rest of Mesoamerica, and hard to find tombs, interest and research just hasn't been the same in West Mexico as it has in eastern Mexico.

Hopefully I can help change that.

Irreversible Conversion of a Water–Ethanol Solution into an Organized Two-Dimensional Network of Alternating Supramolecular Units in a Hydrophobic Zeolite under Pressure by moleculardreams in science

[–]shaggy11072 1 point2 points  (0 children)

This is amazing! Hopefully the technique can be applied to other heterogeneous mixtures to produce all kinds of interesting materials. Any chance that it will be scalable?

Edit: thanks for the gold! Science/Engineering is the place where you can make dreams a reality!

Infants as young as six-months old grasp the complex interactions between a bully, a victim, and an intervening protector - and they root for the brave protector, researchers report this week in Nature Human Behaviour. by mveaMD-PhD-MBA | Clinical Professor/Medicine in science

[–]BiffManly 179 points180 points  (0 children)

I remember seeing another study on this that found babies to be prejudiced little buttheads

They had the babies watch two puppets eat snacks- one eating the snack the baby preferred, the other eating something different. The babies would then prefer the puppet that enjoyed the same snack as them. However, they also cheered when the other puppet got 'hurt'

Here's the video

Scientists discover metal that conducts electricity but not heat, which breaks the Wiedemann-Franz Law, the rule that suggests good conductors of electricity will also be good conductors of thermal energy. by drewiepoodle in science

[–]lagerbaer 4604 points4605 points x2 (0 children)

Awesome! Finally something where my PhD in theoretical solid-state physics can contribute a bit of explanation :)

A lot of the "laws" we have for metals are based on "simple" metals, those where electron-electron interaction plays a very muted role in regards to material properties. In metals such as aluminum, you can sweep all the interaction effects under the rug by just giving the electron a different mass, and then treat it as if they were non-interacting. In that case, if a material is good at conduction electricity, it means each individual electron is free to move through the material as it pleases. But that automatically also makes it a good conductor for heat.

But with transition metals such as Vanadium, you can't really do that any more, because the 3d orbitals (which are the relevant orbitals there) are very close to the nucleus and thus putting more than one electron in that orbital incurs huge Coulomb energy. Thus the field of strongly-interacting systems is a very interesting and important one. Lots of things break down there. For example, Chemists will be familiar with Density Functional Theory to compute electron levels for materials. But that doesn't work for a lot of the transition metal oxides. It'd predict that Nickle Oxide would be a conductor when really it's an insulator, due to the strong on-site Coulomb repulsion between the electrons.

Here's an analogy for the principle at work: Imagine a narrow but straight staircase, where each step has just enough room for one person. There'll be a strong on-site repulsion: You don't want two people on the same step. Now, the only way you guys are able to move is by collectively moving the same way. Either ya'll moving up or ya'll moving down. That'd be electricity: Applying an external field compels you all to move in the same direction, and there's no problem here as long as everyone keeps moving. Heat, on the other hand, would involve everyone trying to move randomly. But that won't work because you'd just get everyone bumping into each other and effectively staying put.

I see the biggest application for this in thermoelectrics: Turning waste heat from, e.g., a car motor, into electricity. The effect exists, but useful commercial applications were hindered by the Wiedemann-Franz law: A temperature difference can generate an electric current, but that current would also carry the heat and thus ruin your temperature difference. With this newly discovered property of Vanadium Oxide, you could get the current while maintaining the heat difference.

EDIT: Obligatory rip inbox. Have to catch some sleep, so I'll have to stop answering for now. /r/askscience is pretty great too btw, and so is physics.stackexchange.com