Metabotropic glutamate receptor 6

GRM6
Identifiers
Aliases	GRM6, CSNB1B, GPRC1F, MGLUR6, mGlu6, glutamate metabotropic receptor 6
External IDs	MGI: 1351343 HomoloGene: 20232 GeneCards: GRM6
Targeted by Drug
eglumetad, DCPG, L-AP4, LY379268
Gene ontology Molecular function • glutamate receptor activity • G-protein coupled receptor activity • protein homodimerization activity • group III metabotropic glutamate receptor activity • signal transducer activity • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity • protein binding Cellular component • integral component of membrane • Golgi apparatus • cell projection • endoplasmic reticulum membrane • membrane • Golgi membrane • plasma membrane • integral component of plasma membrane • dendrite • endoplasmic reticulum • presynaptic membrane • new growing cell tip Biological process • G-protein coupled glutamate receptor signaling pathway • G-protein coupled receptor signaling pathway • detection of visible light • locomotory behavior • response to stimulus • sensory perception of light stimulus • detection of light stimulus involved in visual perception • positive regulation of calcium ion import • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • retina development in camera-type eye • signal transduction • visual perception • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2916	108072
Ensembl	ENSG00000113262	ENSMUSG00000000617
UniProt	O15303	Q5NCH9
RefSeq (mRNA)	NM_000843	NM_173372
RefSeq (protein)	NP_000834	NP_775548.2
Location (UCSC)	Chr 5: 178.98 – 179 Mb	Chr 11: 50.85 – 50.87 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Glutamate receptor, metabotropic 6, also known as GRM6, is a protein which in humans is encoded by the GRM6 gene.

Function

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

See also

• Metabotropic glutamate receptor

Further reading

• Hashimoto T, Inazawa J, Okamoto N, et al. (1997). "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6". Eur. J. Neurosci. 9 (6): 1226–35. doi:10.1111/j.1460-9568.1997.tb01477.x. PMID 9215706. 
• Dhingra A, Lyubarsky A, Jiang M, et al. (2001). "The light response of ON bipolar neurons requires G[alpha]o". J. Neurosci. 20 (24): 9053–8. PMID 11124982. 
• Valerio A, Ferraboli S, Paterlini M, et al. (2001). "Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina". Gene. 262 (1–2): 99–106. doi:10.1016/S0378-1119(00)00547-3. PMID 11179672. 
• Dryja TP, McGee TL, Berson EL, et al. (2005). "Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6". Proc. Natl. Acad. Sci. U.S.A. 102 (13): 4884–9. doi:10.1073/pnas.0501233102. PMC 555731. PMID 15781871. 
• Zeitz C, van Genderen M, Neidhardt J, et al. (2005). "Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram". Invest. Ophthalmol. Vis. Sci. 46 (11): 4328–35. doi:10.1167/iovs.05-0526. PMID 16249515. 
• Zeitz C, Forster U, Neidhardt J, et al. (2007). "Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking". Hum. Mutat. 28 (8): 771–80. doi:10.1002/humu.20499. PMID 17405131. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.