ICI-199,441
From Wikipedia, the free encyclopedia
Identifiers | |
---|---|
|
|
CAS Number | |
PubChem CID | |
ChemSpider | |
ChEMBL | |
Chemical and physical data | |
Formula | C21H24Cl2N2O |
Molar mass | 391.333 g/mol |
3D model (Jmol) | |
|
|
|
|
(what is this?) (verify) |
ICI-199,441 is a drug which acts as a potent and selective κ-opioid agonist, and has analgesic effects.[1][2] It is a biased agonist of the KOR, and is one of a relatively few KOR ligands that is G protein-biased rather than β-arrestin-biased.[1]
See also[edit]
References[edit]
- ^ Costello GF, Main BG, Barlow JJ, Carroll JA, Shaw JS (July 1988). "A novel series of potent and selective agonists at the opioid kappa-receptor". European Journal of Pharmacology. 151 (3): 475–8. PMID 2850924. doi:10.1016/0014-2999(88)90546-8.
- ^ Narita M, Kaneko C, Miyoshi K, Nagumo Y, Kuzumaki N, Nakajima M, Nanjo K, Matsuzawa K, Yamazaki M, Suzuki T (April 2006). "Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala". Neuropsychopharmacology. 31 (4): 739–50. PMID 16123756. doi:10.1038/sj.npp.1300858.
This analgesic-related article is a stub. You can help Wikipedia by expanding it. |