Free fatty acid receptor 3

FFAR3
Identifiers
Aliases	FFAR3, FFA3R, GPR41, GPR42, free fatty acid receptor 3
External IDs	MGI: 2685324 HomoloGene: 82482 GeneCards: FFAR3
Targeted by Drug
butyric acid, isobutyric acid, valeric acid, propionic acid
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • lipid binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • mucosal immune response • G-protein coupled receptor signaling pathway • regulation of norepinephrine secretion • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • negative regulation of blood pressure • immune system process • positive regulation of cytokine production involved in immune response • regulation of hormone biosynthetic process • positive regulation of glucose import in response to insulin stimulus • cellular response to fatty acid • positive regulation of acute inflammatory response to non-antigenic stimulus • positive regulation of chemokine production • inflammatory response • regulation of peptide hormone secretion • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2865	233080
Ensembl	ENSG00000185897	ENSMUSG00000019429
UniProt	O14843	Q3UFD7
RefSeq (mRNA)	NM_005304	NM_001033316
RefSeq (protein)	NP_005295	NP_001028488.1 NP_001028488
Location (UCSC)	Chr 19: 35.36 – 35.36 Mb	Chr 7: 30.85 – 30.86 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Free fatty acid receptor 3 (FFA3) is a G-protein coupled receptor that in humans is encoded by the FFAR3 gene.

See also

• Free fatty acid receptor

Further reading

• Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors.". DNA Cell Biol. 24 (1): 54–61. doi:10.1089/dna.2005.24.54. PMID 15684720. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Brown AJ, Goldsworthy SM, Barnes AA, et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.". J. Biol. Chem. 278 (13): 11312–9. doi:10.1074/jbc.M211609200. PMID 12496283. 
• Le Poul E, Loison C, Struyf S, et al. (2003). "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.". J. Biol. Chem. 278 (28): 25481–9. doi:10.1074/jbc.M301403200. PMID 12711604. 
• Xiong Y, Miyamoto N, Shibata K, et al. (2004). "Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.". Proc. Natl. Acad. Sci. U.S.A. 101 (4): 1045–50. doi:10.1073/pnas.2637002100. PMC 327148. PMID 14722361. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Yonezawa T, Kobayashi Y, Obara Y (2007). "Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line.". Cell. Signal. 19 (1): 185–93. doi:10.1016/j.cellsig.2006.06.004. PMID 16887331.