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A seven-year-old girl is fighting for life following a horrific crash south of Sydney that killed her mother and twin brother on their way to school.
Emergency services were called to the Hume Motorway near Wilton, south of Sydney, at about 7.50am on Tuesday after two cars were involved in a head-on crash in the south-bound lanes, about one kilometre south of the Picton Road turn-off.
A woman and her seven-year-old boy have died in a crash on the Hume Highway near Wilton, a seven-year-old girl is fighting for life with critical injuries.
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A woman and her seven-year-old boy were killed in a car crash on the Hume Highway near Wilton, a seven-year-old twin sister is in a stable condition. Vision: Network Ten
A woman and a seven-year-old boy have died following a horrific crash on the Hume Motorway south of Sydney. A seven-year-old girl is fighting for life in hospital with critical injuries. Vision: Nine News.
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A woman and her seven-year-old boy have died in a crash on the Hume Highway near Wilton, a seven-year-old girl is fighting for life with critical injuries.
Witnesses have reported seeing a Holden Astra travelling north before veering across the median strip and hitting a Mazda four-wheel drive travelling south-bound.
The Mazda was being driven by 49-year-old mother Julie Bullock, who was taking her twins Sienna and Hudson, both 7, to school at Wollondilly.
Crash on the Hume Highway at Pheasants Nest on March 7. Photo: Nine News
Sienna and Hudson were initially trapped in the vehicle before they were freed.
The boy was taken to Liverpool Hospital in a critical condition, but died on Tuesday morning, police said.
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The girl was taken to The Children's Hospital at Westmead with head and chest injuries. Police said she remained in a critical condition on Tuesday afternoon.
The driver of the Holden Astra, also a woman aged 49, is in hospital in a critical condition.
One vehicle overturned in the crash on the Hume Motorway. Photo: Seven News
Police are investigating the cause of the crash, which occurred on a section of the motorway where the north-bound and south-bound lanes are separated by a grass median strip.
A caller to Sydney's 2GB radio described seeing a car's tyre marks leading from the north-bound lanes of the highway through the centre nature strip and on to the south-bound lane.
Another witness also said one of the vehicles was travelling north before crossing the median strip and onto the south-bound lanes.
"I saw the whole thing and called 000 and waiting till police got there was not a good thing to witness," the woman said.
One of the vehicles rolled onto its roof, and motorists said smoke was coming from the wreckage.
Police vehicles escorted the two ambulances as they took the children to hospital.
The motorway was closed to south-bound traffic for nearly five hours, and traffic was diverted onto Picton Road. The motorway re-opened just after 12.30pm.