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The prevention, investigation and prosecution of cybercrime calls for a close cooperation between partners from various sectors. The European Cybercrime Centre (EC3) at Europol has gained practical experience in such forms of multi-disciplinary cooperation and aims to share some of this experience through this note as input for discussions at the Conference on Jurisdictions in Cyberspace on 7-8 March 2016, organised by the Dutch Presidency of the Council of European Union.