World (Five for Fighting song)

"World" is a song written and recorded by American recording artist Five for Fighting. It was released in November 2006 as the second single from the album Two Lights. It reached number 14 on the U.S. Billboard Adult Pop Songs chart.

Content

"World" is an upbeat, piano-driven melody that, like his other singles, paints vivid pictures of human life driven with deep emotion. The song's lyrics are notably more cryptic than in previous singles, but are driven by the chorus hooks, "What kind of world do you want?" and "Be careful what you wish for, history starts now."

Critical reception

Chuck Taylor, of Billboard magazine reviewed the song favorably, calling the song "admittedly more abstract" but the average listener will pick out certain lines and find a relatable message. He goes on to say that "alongside, the piano-driven, orchestrated melody is his most captivating yet lush and instantly memorable."

Music video

The music video for "World" features aspects of the bright side of life including children, marriage and fireworks. There are also references that go with the lyrics including a brief image of a mushroom cloud in a cup of coffee, with a newspaper's headline featuring North Korea's nuclear program. It was directed by Todd Strauss-Schulson.

1977 World 600

The 1977 World 600, the 18th running of the event, was a NASCAR Winston Cup Series racing event that took place on May 29, 1977, at Charlotte Motor Speedway in Concord, North Carolina.

Jim Stacy would become the owner of Krauskopf's old NASCAR team after this event; with the famed red #71 Dodge getting repainted into the white #5. Neil Bonnett, however, would stay on the team as a driver. By 1980, NASCAR had completely stopped tracking the year model of all the vehicles and most teams did not take stock cars to the track under their own power anymore.

Summary

Forty American-born drivers competed here including Benny Parsons, Lennie Pond, Buddy Baker, Darrell Waltrip, and Neil Bonnett. After four hours and twenty-one minutes of racing action, Richard Petty defeated polesitter David Pearson by 30.8 seconds in front of an audience of 115000 people. There were 25 lead changes done in this race in addition to six cautions for 31 laps. While the qualifying top speed was 161.435 miles per hour (259.804 km/h), the average speed of the race was actually 136.676 miles per hour (219.959 km/h). Last-place finisher Ramo Stott would acquire engine trouble on lap 3 of the 400-lap race. The duration of the race was from 12:30 P.M. to 4:41 P.M.; allowing fans to drive to nearby restaurants for supper.

1969 World 600

The 1969 World 600, the 10th running of the event, was a NASCAR Grand National Series event that took place on May 25, 1969 at Charlotte Motor Speedway in Concord, North Carolina.

The race car drivers still had to commute to the races using the same stock cars that competed in a typical weekend's race through a policy of homologation (and under their own power). This policy was in effect until roughly 1975. By 1980, NASCAR had completely stopped tracking the year model of all the vehicles and most teams did not take stock cars to the track under their own power anymore.

Background

Lowe's Motor Speedway is a motorsports complex located in Concord, North Carolina, 13 miles from Charlotte, North Carolina. The complex features a 1.5 miles (2.4 km) quad oval track that hosts NASCAR racing including the prestigious Coca-Cola 600 on Memorial Day weekend and the NEXTEL All-Star Challenge, as well as the Bank of America 500. The speedway was built in 1959 by Bruton Smith and is considered the home track for NASCAR with many race teams located in the Charlotte area. The track is owned and operated by Speedway Motorsports Inc. (SMI) with Marcus G. Smith (son of Bruton Smith) as track president.

Mad (Ne-Yo song)

"Mad" is a song by American pop/R&B singer Ne-Yo. It is the third single from his album Year of the Gentleman and was produced by Stargate and himself.

Music video

The video for the song was directed by Diane Martel. It premiered on AOL on November 25, 2008. The video, shot in black and white, presents a narrative wherein Ne-Yo argues with his girlfriend (played by Faune Chambers). After leaving, in an attempt to save a child from a car accident, someone is fatally hit. At the end of the video, it is revealed that the whole time it has been the ghost of Ne-Yo's character singing, and that it was he who was killed. The video to this song is Part 2 to his song Part of the List.

The music video appears to mirror the 1999 American thriller The Sixth Sense from M. Night Shyamalan, in which Bruce Willis plays a psychologist who is shot by an estranged patient of his. Based on how the film was shot and portrayed, Bruce Willis is shown in many situations as if he is there physically, when in actuality he was murdered by his patient, just as how Ne-Yo appears with his girlfriend, seeming to be there physically and that she is ignoring him due to their earlier argument, when he is actually dead.

Mad1

Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC). This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization. Mad1 recruits the anaphase inhibitor Mad2 to unattached kinetochores and is essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitor of the Mad2-Cdc20 complex. Mad1 is phosphorylated by Mps1 which then leads together with other activities to the formation of the mitotic checkpoint complex (MCC). Thereby it inhibits the activity of the anaphase-promoting complex/cyclosome (APC/C). Homolog’s of Mad1 are conserved in eukaryotes from yeast to mammals.

Introduction

In the early 90s, yeast genes were identified which mutations resulted in a defect in mitotic arrest in response to microtubule disassembly (mitotic arrest deficient genes - MAD genes). This cells showed during division no mitotic arrest in the presence of microtubule polymerization inhibitors and were therefore not able to delay cell division. The genes identified included the MAD1, MAD2 and MAD3 genes. They are conserved in all eukaryotes and are involved in a pathway that is active in prometaphase to prevent the premature separation of sister chromatids and constitute the so-called spindle assembly checkpoint(SAC). This checkpoint monitors the status of chromosome attachment to the mitotic spindle and inhibits the metaphase to anaphase transition by preventing the activation of the anaphase-promoting complex/cyclosome (APC/C), and thereby the degradation of cell cycle regulators. Mad1 is in this pathway accumulated at unattached kinetochores and acts as a sensor for unattached kinetochores in this machinery.

Mad2

Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a kinetochore binding protein was missing. The protein was shown to be present at unattached kinetochores and antibody inhibition studies demonstrated it was essential to execute a block in the metaphase-to-anaphase transition in response to the microtubule poison nocodazole. Subsequent cloning of the Xenopus laevis orthologue, facilitated by the sharing of the human sequence, allowed for the characterization of the mitotic checkpoint in egg extracts.

Metaphase-to-anaphase transition

Ryan (surname)

Ryan is a common Irish surname, as well as being a common given name.

There are several possible origins for the surname. In certain cases it can be a simplified form of Mulryan. In some cases the surname may be derived from the Irish Gaelic Ó Riagháin (modern Irish Ó Riain), meaning "descendant of Rían"; or Ó Maoilriain "descendant of Maoilriaghain", or Ó Ruaidhín "descendant of the little red one". The old Gaelic personal name Rían is of uncertain origin. It may be derived from the Gaelic rí, meaning "king".

The surname Ryan has been confused with the surname Regan, which is derived from Ó Ríagáin, meaning "descendant of Riagán".

List of persons with the surname Ryan

A–D