Anileridine
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Clinical data | |
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AHFS/Drugs.com | Monograph |
Routes of administration |
Tablets, injection |
ATC code | N01AH05 (WHO) |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | > 95% |
Metabolism | Hepatic |
Identifiers | |
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CAS Number | 144-14-9 ![]() |
PubChem (CID) | 8944 |
IUPHAR/BPS | 7115 |
DrugBank | DB00913 ![]() |
ChemSpider | 8600 ![]() |
UNII | 71Q1A3O279 ![]() |
KEGG | D02941 ![]() |
ChEBI | CHEBI:61203 ![]() |
ChEMBL | CHEMBL1201347 ![]() |
Chemical and physical data | |
Formula | C22H28N2O2 |
Molar mass | 352.47 g/mol |
3D model (Jmol) | Interactive image |
Melting point | 83 °C (181 °F) |
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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.
Anileridine is no longer manufactured in the US or Canada.[2] Anileridine is in Schedule II of the Controlled Substances Act 1970 of the United States as ACSCN 9020 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.83 for the dihydrochloride and 0.73 for the phosphate [3] It is also under international control per UN treaties.
Administration[edit]
Pharmacokinetics[edit]
Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[5] It is mostly metabolized by the liver.
References[edit]
- ^ U.S. Patent 2,897,204
- ^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.
- ^ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
- ^ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
- ^ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.
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