Levobunolol
Из Википедије, слободне енциклопедије
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(IUPAC) ime | |
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(S)-5[3-(tert-butilamino)-2-hidroksipropil]oksi3,4-dihidronaftalen-1(2H)-on | |
Klinički podaci | |
Robne marke | Betagan |
AHFS/Drugs.com | Monografija |
MedlinePlus | a686011 |
Identifikatori | |
CAS broj | 47141-42-4 |
ATC kod | S01ED03 |
PubChem[1][2] | 39468 |
DrugBank | DB01210 |
ChemSpider[3] | 36089 |
UNII | G6317AOI7K ![]() |
KEGG[4] | D08115 ![]() |
ChEBI | CHEBI:6438 ![]() |
ChEMBL[5] | CHEMBL1201237 ![]() |
Hemijski podaci | |
Formula | C17H25NO3 |
Mol. masa | 291,385 g/mol |
SMILES | eMolekuli & PubHem |
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Farmakokinetički podaci | |
Poluvreme eliminacije | 20 sata |
Farmakoinformacioni podaci | |
Trudnoća | ? |
Pravni status | ℞-only (SAD) |
Način primene | Topikalno (kapi za oči) |
Levobunolol (AK-Beta, Liquifilm, Betegan) je neselektivni beta blokator. On se koristi topikalno za tretiranje glaukoma.
Reference[уреди]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. doi:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. doi:10.1093/nar/gkr777. PMID 21948594.
Literatura[уреди]
- Ishibashi T, Yokoi N, Kinoshita S (2003). „Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.”. Cornea 22 (8): 709–15. doi:10.1097/00003226-200311000-00001. PMID 14576520.
- Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). „[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]”. Nippon Ganka Gakkai Zasshi 103 (7): 544–50. PMID 10443129.
- Leung M, Grunwald J (1997). „Short-term effects of topical levobunolol on the human retinal circulation.”. Eye 11 (3): 371–6. doi:10.1038/eye.1997.78. PMID 9373479.
Spoljašnje veze[уреди]
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