Methazolamide
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Clinical data | |
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AHFS/Drugs.com | Monograph |
MedlinePlus | a601233 |
Pregnancy category |
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Routes of administration |
Oral |
ATC code | S01EC05 (WHO) |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | ~55% |
Biological half-life | ~14 hours |
Identifiers | |
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Synonyms | N-(3-Methyl-5-sulfamoyl-3H-1,3,4-thiadiazol-2-ylidene) ethanamide |
CAS Number | 554-57-4 |
PubChem (CID) | 4100 |
IUPHAR/BPS | 6828 |
DrugBank | DB00703 |
ChemSpider | 3958 |
UNII | W733B0S9SD |
KEGG | D00655 |
ChEMBL | CHEMBL19 |
ECHA InfoCard | 100.008.243 |
Chemical and physical data | |
Formula | C5H8N4O3S2 |
Molar mass | 236.274 g/mol |
3D model (Jmol) | Interactive image |
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Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.
References[edit]
- Iyer G, Bellantone R, Taft D (1999). "In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.". J Pharmacokinet Biopharm. 27 (1): 45–66. doi:10.1023/A:1020630712388. PMID 10533697.
- RxList. "Neptazane". Retrieved August 20, 2006.
- Shirato S, Kagaya F, Suzuki Y, Joukou S (1997). "Stevens–Johnson syndrome induced by methazolamide treatment.". Arch Ophthalmol. 115 (4): 550–3. doi:10.1001/archopht.1997.01100150552021. PMID 9109770.
- Skorobohach B, Ward D, Hendrix D (2003). "Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.". Am J Vet Res. 64 (2): 183–7. doi:10.2460/ajvr.2003.64.183. PMID 12602587.
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