WAY-208,466

WAY-208,466
Clinical data
ATC code	none;
Identifiers
	IUPAC name N'-[(2Z)-4-(2,4-dichlorophenyl)-3-(2-methylpropyl)-1,3-thiazol-2(3H)-ylidene]-2-(pyrazin-2-yloxy)acetohydrazide;
CAS Number	?;
PubChem CID	11820788;
ChemSpider	9995440;
ChEMBL	CHEMBL571858;
Chemical and physical data
Formula	C19H19Cl2N5O2S
Molar mass	452.36 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=C(N\N=C1/S\C=C(/N1CC(C)C)c2ccc(Cl)cc2Cl)COc3nccnc3 ;

WAY-208,466 is a potent and highly selective full agonist of the 5-HT₆ receptor.^[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.^[1] Animal studies have shown that WAY-208,466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.^[1]^[2]

References[edit]

^ ^a ^b ^c Schechter LE, Lin Q, Smith DL, et al. (May 2008). "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology. 33 (6): 1323–35. doi:10.1038/sj.npp.1301503. PMID 17625499.
^ Carr GV, Schechter LE, Lucki I (March 2010). "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology. 213 (2–3): 499–507. doi:10.1007/s00213-010-1798-7. PMC 2910165. PMID 20217056.

v t e Anxiolytics (N05B)

5-HT_1A agonists	Buspirone Tandospirone

GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam Others: Alpidem^‡ Barbiturates Carbamates Chlormezanone^‡ Ethanol Etifoxine; Herbs: Kava Skullcap Valerian

α₂δ VDCC blockers	Gabapentin Gabapentin enacarbil Phenibut Pregabalin

Antidepressants	SSRIs SNRIs SARIs TCAs TeCAs MAOIs; Others: Agomelatine Bupropion Vilazodone Vortioxetine

Sympatholytics	Beta blockers (e.g., propranolol) Clonidine Dexmedetomidine Guanfacine Prazosin

Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum

Clinical data


ATC code	none
Identifiers
IUPAC name N'-[(2Z)-4-(2,4-dichlorophenyl)-3-(2-methylpropyl)-1,3-thiazol-2(3H)-ylidene]-2-(pyrazin-2-yloxy)acetohydrazide
CAS Number	?
PubChem CID	11820788
ChemSpider	9995440
ChEMBL	CHEMBL571858
Chemical and physical data
Formula	C₁₉H₁₉Cl₂N₅O₂S
Molar mass	452.36 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(N\N=C1/S\C=C(/N1CC(C)C)c2ccc(Cl)cc2Cl)COc3nccnc3