Pirbuterol

Pirbuterol
Clinical data
Trade names	Maxair
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a601096
Pregnancy; category	C;
Routes of; administration	Inhalational (MDI)
ATC code	R03AC08 (WHO) R03CC07 (WHO)
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (RS)-6-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-ol;
CAS Number	38029-10-6
PubChem (CID)	4845
IUPHAR/BPS	7272
DrugBank	DB01291
ChemSpider	4679
UNII	OG645J8RVW
KEGG	D08387
ChEMBL	CHEMBL1094966
Chemical and physical data
Formula	C12H20N2O3
Molar mass	240.30 g/mol; 300.3 g/mol (acetate)
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
	SMILES Oc1ccc(nc1CO)C(O)CNC(C)(C)C ;
	InChI InChI=1S/C12H20N2O3/c1-12(2,3)13-6-11(17)8-4-5-10(16)9(7-15)14-8/h4-5,11,13,15-17H,6-7H2,1-3H3 ; Key:VQDBNKDJNJQRDG-UHFFFAOYSA-N ;
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Pirbuterol (trade name Maxair) is a short-acting β₂ adrenoreceptor agonist with bronchodilating action used in the treatment of asthma, available (as pirbuterol acetate) as a breath-activated metered-dose inhaler (Maxair Autohaler).

Clinical use[edit]

Pirbuterol is used in asthma for reversal of acute bronchospasm, and also as a maintenance medication to prevent future attacks. It should be used in patients 12 years of age and older with or without concurrent theophylline and/or inhaled corticosteroid.^[1]^[2]

Mode of action[edit]

Pharmacokinetics[edit]

After inhalation of doses up to 800 μg (twice the maximum recommended dose) systemic blood levels of pirbuterol are below the limit of assay sensitivity (2–5 ng/ml). A mean of 51% of the dose is recovered in urine as pirbuterol plus its sulfate conjugate following administration by aerosol. Pirbuterol is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about two hours.^[1]

Adverse effects[edit]

References[edit]

^ ^a ^b "Maxair Autohaler (pirbuterol acetate inhalation aerosol) For Oral Inhalation Only. U.S. Full Prescribing Information". 3M Pharmaceuticals. Northridge, CA 91324. Retrieved 7 March 2016.
^ Bianchi, Marina; Clavenna, Antonio; Bonati, Maurizio (2010). "Inter-country variations in anti-asthmatic drug prescriptions for children. Systematic review of studies published during the 2000–2009 period". European Journal of Clinical Pharmacology. 66 (9): 929–936. doi:10.1007/s00228-010-0845-y. ISSN 0031-6970.

External links[edit]

RxList: Maxair (Pirbuterol)

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

[PI-1] "Maxair Autohaler (pirbuterol acetate inhalation aerosol) For Oral Inhalation Only. U.S. Full Prescribing Information". 3M Pharmaceuticals. Northridge, CA 91324. Retrieved 7 March 2016.

[BianchiClavenna2010-2] Bianchi, Marina; Clavenna, Antonio; Bonati, Maurizio (2010). "Inter-country variations in anti-asthmatic drug prescriptions for children. Systematic review of studies published during the 2000–2009 period". European Journal of Clinical Pharmacology. 66 (9): 929–936. doi:10.1007/s00228-010-0845-y. ISSN 0031-6970.

[1]

[2]

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Phentermines	Stimulants: Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens: MDPH MDMPH Others: Cericlamine

Cathinones	Stimulants: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB Pentedrone Pentylone Radafaxine Entactogens: 3,4-DMMC 3-MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone

Phenylisobutylamines	Entactogens: 4-CAB 4-MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants: Phenylisobutylamine

Phenylalkylpyrrolidines	Stimulants: α-PBP α-PHP α-PPP α-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Naphyrone PEP Prolintane Pyrovalerone

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Pirbuterol

Contents

Clinical use[edit]

Mode of action[edit]

Pharmacokinetics[edit]

Adverse effects[edit]

References[edit]

External links[edit]

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