Bag (Bužim)

Bag is a settlement in Bužim, in Bosnia and Herzegovina.

External links

Coordinates: 44°00′N 18°07′E / 44.000°N 18.117°E / 44.000; 18.117

BAG3

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy (CASA).

Function

BAG proteins compete with Hip-1 for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases such as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively. It has also been shown to be the cause of familial dilated cardiomyopathy. That BAG3 mutations are responsible for familial dilated cardiomyopathy is confirmed by another study describing 6 new molecular variants (2 missense and 4 premature Stops ). Moreover, the same publication reported that BAG3 polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus.

BAG1

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Interactions

BAG1 has been shown to interact with:

Black

Black is the darkest color, the result of the absence of or complete absorption of light. It is the opposite of white (the combined spectrum of color or light). It is an achromatic color, literally a color without color or hue. It is one of the four primary colors in the CMYK color model, along with cyan, yellow, and magenta, used in color printing to produce all the other colors.

Black was one of the first colors used by artists in neolithic cave paintings. In the 14th century, it began to be worn by royalty, the clergy, judges and government officials in much of Europe. It became the color worn by English romantic poets, businessmen and statesmen in the 19th century, and a high fashion color in the 20th century.

In the Roman Empire, it became the color of mourning, and over the centuries it was frequently associated with death, evil, witches and magic. According to surveys in Europe and North America, it is the color most commonly associated with mourning, the end, secrets, magic, force, violence, evil, and elegance.

White and Black in chess

In chess, the player who moves first is referred to as "White" and the player who moves second is referred to as "Black". Similarly, the pieces that each conducts are called, respectively, "the white pieces" and "the black pieces". The pieces are often not literally white and black, but some other colors (usually a light color and a dark color, respectively). The 64 squares of the chessboard, which is colored in a checkered pattern, are likewise referred to as "white squares" or "light squares" on the one hand, and "black squares" or "dark squares" on the other. In most cases, the squares are not actually white and black, but a light color and a contrasting dark color. For example, the squares on plastic boards are often off-white ("buff") and green, while those on wood boards are often light brown and dark brown.

In old chess writings, the sides are often called Red and Black, because those were the two colors of ink then commonly available when hand-drawing or printing chess position diagrams.

Black (Lita Ford album)

Black is Lita Ford's sixth studio album and featured a change of style in her music, compared to her other albums. Black sees Ford move into other musical styles such as blues and grunge, while still maintaining her metal and rock roots. There would be a 14-year gap between Black and her next studio album, 2009's Wicked Wonderland.

Track listing

All songs were written by Michael Dan Ehmig and Lita Ford, except where noted.

Personnel

Musicians

Doctors (TV series)

Doctors is a British medical soap opera which first broadcast in the United Kingdom on BBC One on 26 March 2000. Set in the fictional Midlands town of Letherbridge, defined as being in the city of Birmingham, the soap follows the staff of a doctor's surgery, and their families.

History

Doctors is produced by BBC Birmingham and is screened on BBC One, with the first episode broadcast on 26 March 2000. It was created by Chris Murray, with Mal Young developing it and Carson Black the original producer. The show has been shown at lunchtime since its inception, originally at 12.30pm as a lead-in to the BBC's One O'Clock News. After it was temporarily moved to allow for extended news coverage of the 11 September 2001 attacks, its regular slot changed to 2:10 pm, following directly after Neighbours, after ratings rose to a 25% audience share. When the BBC lost Neighbours to Channel 5 in January 2008, it moved into the Australian soap's old slot of 1:45pm. For a brief trial period in Summer 2000, selected episodes from the first series were shown on Fridays at 7 pm and from 16 February 2009, the show began transmitting in high definition on BBC HD at 4:00pm the same day.