PWZ-029
From Wikipedia, the free encyclopedia
 |
|
| Identifiers | |
|---|---|
|
|
| PubChem (CID) | 9971547 |
| ChemSpider | 8147139 |
| ChEMBL | CHEMBL45346  |
| Chemical and physical data | |
| Formula | C14H14ClN3O2 |
| Molar mass | 291.732 g/mol |
| 3D model (Jmol) | Interactive image |
|
|
|
|
 (what is this?) (verify) |
|
PWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys,[1] It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.[2]
See also[edit]
References[edit]
- ^ US Patent application US2006/258643 A1
- ^ Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 2008 May 7;1208:150-9. doi:10.1016/j.brainres.2008.02.020 PMID 18394590
 |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
