Metilfenidat
Из Википедије, слободне енциклопедије
IUPAC ime | |
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metil fenil(piperidin-2-il)acetat
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Klinički podaci | |
Prodajno ime | Concerta, Methylin, Ritalin, Equasym XL |
Drugs.com | Monografija |
MedlinePlus | a682188 |
Podaci o licenci |
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Kategorija trudnoće | |
Opojna droga | Moderate |
Način primene | Oralno, transdermalno |
Pravni status | |
Pravni status |
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Farmakokinetički podaci | |
Bioraspoloživost | ~30% (opseg: 11–52%) |
Vezivanje proteina | 10-33% |
Metabolizam | Hepatički (80%) |
Poluvreme eliminacije | 3-4 sata (d-enantiomer), 1-3 sata (l-enantiomer) |
Izlučivanje | Urin (90%) |
Identifikatori | |
CAS broj | 113-45-1 |
ATC kod | N06BA04 (WHO) |
PubChem | CID 4158 |
DrugBank | DB00422 |
ChemSpider | 4015 |
UNII | 207ZZ9QZ49 |
KEGG | D04999 |
ChEBI | CHEBI:6887 |
ChEMBL | CHEMBL796 |
Hemijski podaci | |
Formula | C14H19NO2 |
Molarna masa | 233,30 g/mol |
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Fizički podaci | |
Tačka topljenja | 214 °C (417 °F) |
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Metilfenidat (Concerta, Methylin, Ritalin, Equasym XL) je psihostimulišući lek i supstituisani fenetilamin koji je odobren tretman hiperkinetičkog poremećaja (ADHD), posturalnog ortostatskog tahikardnog sindroma i narkolepsije. Originalni patent je posedovalo preduzeće CIBA. FDA je odobrila ovaj lek 1955. za tretiranje hiperaktivnosti. Propisivan je od početka 1960-tih. Nivo proskripcija je znatno porastao tokom 1990-tih kad je ADHD dijagnoza postala šire prihvaćena.[1][2]
Reference[уреди]
- ↑ When Was Ritalin Invented?, citing Lawrence Diller: "Running on Ritalin", 1999
- ↑ Lange, K.W. et al.: The history of attention deficit hyperactivity disorder. In: Attention Deficit Hyperactivity Disorders, 2(4):241-55. doi: 10.1007/s12402-010-0045-8.
Literatura[уреди]
- Gardiner Harris (3. 2. 2012). = 3. 2. 2012. „F.D.A. Finds Short Supply of Attention Deficit Drugs” . The New York Times. Архивирано из оригинала на датум 3. 2. 2012. Приступљено 3. 2. 2012. »(Archived by WebCite® at [1])«
- L. Alan Sroufe (28. 1. 2012). = 3. 2. 2012. „Ritalin Gone Wrong - Opinion - Children\'s A.D.D.Drugs Don\'t Work Long-Term” . The New York Times. Архивирано из оригинала на датум 3. 2. 2012. Приступљено 3. 2. 2012. »(Archived by WebCite® at [2])«
- {Cite journal|author=Lakhan SE, Hagger-Johnson GE |title=The impact of prescribed psychotropics on youth |journal=Clin Pract Epidemol Ment Health |volume=3 |page=21 |year=2007 |pmid=17949504 |pmc=2100041 |doi=10.1186/1745-0179-3-21 |url=http://www.cpementalhealth.com/content/3/1/21 |issue=1}}
- Drug Enforcement Administration, Greene, S.H., Response to CHADD petition concerning Ritalin, 1995, August 7. Washington, DC: DEA, U.S. Department of Justice.
- New Research Helps Explain Ritalin's Low Abuse Potential When Taken As Prescribed – 09/29/1998. Nih.gov. Retrieved on 2011-04-30.
- Weinberg WA, Brumback RA (1992). „The myth of attention deficit-hyperactivity disorder: symptoms resulting from multiple causes”. J. Child Neurol. 7 (4): 431—45; discussion 446—61. doi:10.1177/088307389200700420. PMID 1469255.
- Presenters: Joan Hamburg and Dr. Harold Koplewicz (3. 2. 2012). „Are we over medicating our kids? Speaking with Dr. Harold Koplewicz of @ChildMindDotOrg”. Joan Hamburg Show (Radio)http://wor710.com/topic/play_window.php?audioType=Episode&audioId=5670191 . 1:11 into the complete two part show - 2 мин. WOR Radio Network. WOR. </ref>
Spoljašnje veze[уреди]
Metilfenidat na Vikimedijinoj ostavi. |
- Metilfenidat на сајту DMOZ (енглески)
- Department of Energy September 29, 1998 press release on Ritalin at Brookhaven National Laboratory
- Erowid methylphenidate vault
- U.S. National Library of Medicine: Drug Information Portal – Methylphenidate