Tuaminoheptane
Names
IUPAC name
Identifiers
123-82-0 Y
6240-90-0 R Y
44745-29-1 S Y
3D model (Jmol )
Interactive image
635676, 4652352 R , 1719086 S
ChEMBL
ChEMBL123693 Y
ChemSpider
5401 Y
5360930 R Y
2016267 S Y
ECHA InfoCard
100.004.233
EC Number
204-655-522
KEGG
D07371 Y
MeSH
tuamine
PubChem
5603
6992808 R
2734517 S
RTECS number
MQ5425000
R01AB08 (WHO ) (combinations)
UNII
Z0420GYD84 Y
UN number
1993
InChI=1S/C7H17N/c1-3-4-5-6-7(2)8/h7H,3-6,8H2,1-2H3
Y
Key: VSRBKQFNFZQRBM-UHFFFAOYSA-N
Y
Properties
C 7 H 17 N
Molar mass
115.22 g·mol−1
Appearance
Colourless liquid
Density
0.766 g/mL
Boiling point
142.1 °C; 287.7 °F; 415.2 K
log P
2.429
1.418–1.419
Pharmacology
R01AA11 (WHO )
Hazards
GHS pictograms
GHS signal word
WARNING
H226 , H315 , H319 , H335
P261 , P305+351+338
Xi
R-phrases
R10 , R36/37/38
S-phrases
S26 , S36
Flash point
54 °C (129 °F; 327 K)
Lethal dose or concentration (LD , LC ):
130 mg kg−1 (subcutaneous, rat)
Related compounds
Related alkanamines
Related compounds
Octamoxin
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tuaminoheptane (or tuamine ) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor .[2] However, it can cause skin irritation,[3] which limits its usefulness as a nasal decongestant. Oral preparations were once available, but are no longer produced. Side effects associated with the use of tuaminoheptane can include shortness of breath, tachycardia and hypertension .
Tuaminoheptane is on the 2011 list of prohibited substances published by the World Anti-Doping Agency .
See also [ edit ]
References [ edit ]
^ "tuamine - Compound Summary" . USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. Retrieved 31 May 2012 .
^ Delicado, E. G.; Fideu, M. D.; Miras-Portugal, M. T.; Pourrias, B.; Aunis, D. (1990). "Effect of tuamine, heptaminol and two analogues on uptake and release of catecholamines in cultured chromaffin cells". Biochemical Pharmacology . 40 (4): 821–825. doi :10.1016/0006-2952(90)90322-C . PMID 2386550 .
^ Raoux, M.; Colomban, C.; Delmas, P.; Crest, M. (2007). "The amine-containing cutaneous irritant heptylamine inhibits the volume-regulated anion channel and mobilizes intracellular calcium in normal human epidermal keratinocytes". Molecular Pharmacology . 71 (6): 1685–1694. doi :10.1124/mol.106.033324 . PMID 17384225 .
External links [ edit ]
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