File:ΔFosB accumulation.svg

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Original file ‎(SVG file, nominally 400 × 440 pixels, file size: 227 KB)

Summary[edit]

Description
English: The top graph depicts the acute expression/induction of various Fos family proteins in mesolimbic dopamine neurons following an acute/initial exposure to an addictive drug.

The bottom graph depicts the accumulating expression of phosphorylated ΔFosB isoforms in the D1-type medium spiny neurons of the nucleus accumbens following repeated overdose on an addictive drug every 12 hours (upticks in expression occur at half-day intervals).

This image was redrawn manually in inkscape and based upon the more-or-less identical graphs from either of these sources:

  1. Malenka RC, Nestler EJ, Hyman SE () Sydor A, Brown RY , ed. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.), McGraw-Hill Medical, p. 110 ISBN: 9780071481274. “Figure 4–27”
  2. Nestler EJ, Barrot M, Self DW (September 2001). "DeltaFosB: a sustained molecular switch for addiction". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11042–11046. DOI:10.1073/pnas.191352698. PMID 11572966. PMC: 58680. "Figure 1"
Date
Source Own work based upon http://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680/figure/F1
Author Seppi333
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Date/TimeThumbnailDimensionsUserComment
current07:12, 8 February 2015Thumbnail for version as of 07:12, 8 February 2015400 × 440 (227 KB)Seppi333 (talk | contribs)move line
07:11, 8 February 2015Thumbnail for version as of 07:11, 8 February 2015400 × 440 (227 KB)Seppi333 (talk | contribs)move line
06:58, 8 February 2015Thumbnail for version as of 06:58, 8 February 2015400 × 440 (227 KB)Seppi333 (talk | contribs)going for a massive column of uploads! (moving text leftward)
06:57, 8 February 2015Thumbnail for version as of 06:57, 8 February 2015400 × 440 (227 KB)Seppi333 (talk | contribs)same as below
06:56, 8 February 2015Thumbnail for version as of 06:56, 8 February 2015400 × 440 (227 KB)Seppi333 (talk | contribs)Reup: because svg check is down and inkscape sucks
06:52, 8 February 2015Thumbnail for version as of 06:52, 8 February 2015400 × 450 (227 KB)Seppi333 (talk | contribs)User created page with UploadWizard
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Width 400
Height 440
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