Queen Letizia of Spain wears her favourite Hugo Boss dress

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Letizia, 44, joined her husband King Felipe VI at a scientific research centre
The elegant royal has worn her £538 Hugo Boss number at least four times
Mother-of-two teamed her leather dress with patent heels and a chic blazer

By Unity Blott and Kate Thomas for MailOnline

Published: 13:55 EST, 9 February 2017 | Updated: 13:55 EST, 9 February 2017

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She has a reputation for being one of the best-dressed royals in Europe.

And on Thursday, Queen Letizia of Spain showed off her style credentials once again as she stepped out in her favourite Hugo Boss dress for an engagement in Madrid.

Letizia, 44, wore her beloved £528 lambskin leather number with a fitted blazer as she joined her husband King Felipe VI for a visit to the National Center for Cardiovascular Research Foundation (CNIC) in the Spanish capital.

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Queen Letizia of Spain showed off her style credentials once again as she stepped out in her favourite Hugo Boss dress for an engagement in Madird

Looking every inch the stylish royal, the mother-of-two teamed her form-fitting dress with a pair of patent court heels and a cross-body bag, adding a slick of berry lipstick.

The elegant royal, known for her love of a high street bargain, has worn the dress on at least four separate occasions.

Set up in 1999, the CNIC, a leading international research centre, is dedicated to understanding cardiovascular health and disease and translating this knowledge into improved patient care.

The style icon, pictured in October 2015, has worn the elegant get-up on several occasions including a solo tour of Vienna in 2014 and for a meeting of the Royal Council on Disability

Letizia paired the £528 lambskin leather dress with a fitted blazer as she joined her husband King Felipe VI for a visit to the National Center for Cardiovascular Research Foundation (CNIC)

Looking every inch the stylish royal, the mother-of-two teamed her form-fitting dress with a pair of patent court heels and a cross-body bag, adding a slick of berry lipstick

Elegant: Queen Letizia of Spain was once again immaculately put together when she attended the Expansion newspaper's 30th anniversary at the Palace Hotel in Madrid, Spain on Tuesday

Yesterday, Letizia was was once again immaculately put together when she attended the Expansion newspaper's 30th anniversary at Madrid's Palace Hotel.

The 44-year-old royal looked incredible in a simple and sophisticated black dress with pretty lace detailing on the sleeves.

The demure, knee-length skirt boasted a subtle applique pattern and was set off with simple stilettos.

Letizia ensured her hair and make-up took centre stage, sweeping her brunette tresses up into a slick braided updo.

Classic look: Letizia ensured her hair and make-up took centre stage, sweeping her brunette tresses up into a slick braided up-do with a simple and sophisticated black dress

Royal outing: Letizia was flanked by her husband King Felipe VI of Spain at the celebrations. Her show-stopping dress featured embellishment and pretty lace detailing on the sleeves

She completed her glamorous look with a striking pair of chandelier earrings, and a slick of shimmery red lipstick.

King Felipe VI was also in attendance, joining his wife to celebrate the publication's landmark anniversary.

The Spanish royals have had a whirlwind few weeks of official engagements following their return to royal duties after the Christmas break.

Letizia, who is mother to Princess Leonor, 11 and Princess Sofía, nine, wed Felipe, 49, in 2004.

Striking: She completed her glamorous look with a striking pair of chandelier earrings, and a slick of shimmery red lipstick as she joined her husband King Felipe VI

Braided beauty: Letizia ensured her hair and make-up took centre stage, sweeping her brunette tresses up into a slick braided updo

Joint outing: Letizia, who is mother to Princess Leonor, 11 and Princess Sofía, nine, wed Felipe, 49, in 2004. The Spanish royals have had a whirlwind few weeks of official engagements

Close to her heart: The Expansion newspaper event was no doubt close to former journalist and newsreader Letizia's heart. The royal married into the Spanish monarchy in 2004

She married into the Spanish monarchy following a successful career as a journalist and newsreader.

She was previously married to Alonso Guerrero Pérez, a writer, but the pair divorced after just a year and by 2003 Letizia had announced her engagement to Felipe, then the Prince of Asturias.

King Juan Carlos abdicated in 2014 in favour of his 48-year-old son, now King Felipe VI.