VUF-5681
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Names | |
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IUPAC name
4-[3-(1H-imidazol-5-yl)propyl]piperidine
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Identifiers | |
768358-61-8 ![]() |
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3D model (Jmol) | Interactive image |
ChemSpider | 8505701 ![]() |
PubChem | 10330240 |
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Properties | |
C11H19N3 | |
Molar mass | 193.288 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.[1] However while VUF-5681 blocks the activity of more potent H3 agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]
References[edit]
- ^ Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. PMID 16769092
- ^ Baker, JG (2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC pharmacology. 8: 9. doi:10.1186/1471-2210-8-9. PMC 2430196
. PMID 18538007.
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