Buclizine
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Clinical data | |
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
ATC code | R06AE01 (WHO) |
Identifiers | |
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CAS Number | 82-95-1 ![]() |
PubChem (CID) | 6729 |
IUPHAR/BPS | 7134 |
DrugBank | DB00354 ![]() |
ChemSpider | 6473 ![]() |
UNII | 0C94V6X681 ![]() |
ChEBI | CHEBI:3205 ![]() |
ChEMBL | CHEMBL1201271 ![]() |
ECHA InfoCard | 100.001.317 |
Chemical and physical data | |
Formula | C28H33ClN2 |
Molar mass | 433.028 g/mol |
3D model (Jmol) | Interactive image |
Chirality | Racemic mixture |
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Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.[1]
In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]
References[edit]
- ^ Mostafa, G. A. E.; Al-Badr, A. A. (2011). "Buclizine". Profiles of drug substances, excipients, and related methodology. Profiles of Drug Substances, Excipients and Related Methodology. 36: 1–33. doi:10.1016/B978-0-12-387667-6.00001-4. ISBN 9780123876676. PMID 22469258.
- ^ Behrendt, W. A.; Cserepes, J. (1985). "Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats". Pharmatherapeutica. 4 (5): 322–331. PMID 4070325.
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Simple piperazines (no additional rings) |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
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Pyrimidinylpiperazines | |
Pyridinylpiperazines | |
Benzo(iso)thiazolylpiperazines | |
Tricyclics (piperazine attached via side chain) |
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Others/Uncategorized |
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