Antazoline
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Clinical data | |
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Trade names | Vasocon-a |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration |
Topical (nasal, eye drops) |
ATC code | R01AC04 (WHO) R06AX05 (WHO) |
Identifiers | |
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CAS Number | 91-75-8 ![]() |
PubChem (CID) | 2200 |
IUPHAR/BPS | 7116 |
DrugBank | DB08799 ![]() |
ChemSpider | 2115 ![]() |
UNII | DHA8014SS1 ![]() |
KEGG | D07458 ![]() |
ChEBI | CHEBI:84115 ![]() |
ChEMBL | CHEMBL1305 ![]() |
ECHA InfoCard | 100.001.904 |
Chemical and physical data | |
Formula | C17H19N3 |
Molar mass | 265.353 g/mol |
3D model (Jmol) | Interactive image |
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Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.[1] The drug is a Histamine H1 receptor antagonist:[2] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
References[edit]
- ^ Abelson MB, Allansmith MR, Friedlaender MH (1980). "Effects of topically applied ocular decongestant and antihistamine". Am J Ophthalmol. 90 (2): 254–7. doi:10.1016/s0002-9394(14)74864-0. PMID 7425039.
- ^ Noguchi, Seiji; Inukai, Toshiya; Kuno, Takayoshi; Tanaka, Chikako (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628.
Decongestants and other nasal preparations (R01)
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