Fenmetozole
From Wikipedia, the free encyclopedia
 |
|
| Clinical data | |
|---|---|
| ATC code | None |
| Identifiers | |
|
|
| CAS Number | 41473-09-0 23712-05-2 (HCl) |
| PubChem (CID) | 32049 |
| ChemSpider | 29721 |
| UNII | C15WFN6GMO  |
| ChEMBL | CHEMBL50472 |
| Chemical and physical data | |
| Formula | C10H10Cl2N2O |
| Molar mass | 245.11 g/mol |
| 3D model (Jmol) | Interactive image |
|
|
Fenmetozole (DH-524) is a drug which was patented as an antidepressant,[1][2] but was later studied as an antagonist of the effects of ethanol, though results were poor and it even increased its effects in some cases.[3][4][5][6][7] It acts as an α2-adrenergic receptor antagonist similarly to other imidazoles like idazoxan.[8] It was never marketed.[2]
Fenoxazoline has the precise same formula, albeit instead of the 3',4'-dich, an ortho-isopropyl group was chosen instead.
References[edit]
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
- ^ a b David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
- ^ McNamee HB, Mendelson JH, Korn J (June 1975). "Fenmetozole in acute alcholol intoxication in man". Clinical Pharmacology and Therapeutics. 17 (6): 735–7. PMID 1095283.
- ^ Griffis LC, Bright TP, Cerimele BJ, Forney RB (September 1978). "Combined effects of fenmetozole and ethanol". Clinical Pharmacology and Therapeutics. 24 (3): 350–3. PMID 357069.
- ^ Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA (1980). "An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function". Psychopharmacology. 69 (2): 149–55. doi:10.1007/BF00427641. PMID 6256788.
- ^ Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR (1981). "Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex". Alcoholism: Clinical and Experimental Research. 5 (3): 386–92. doi:10.1111/j.1530-0277.1981.tb04921.x. PMID 6792942.
- ^ Frye GD, Breese GR (1981). "An evaluation of the locomotor stimulating action of ethanol in rats and mice". Psychopharmacology. 75 (4): 372–9. doi:10.1007/BF00435856. PMID 6803283.
- ^ Stillings MR, England CD, Welbourn AP, Smith CF (September 1986). "Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". Journal of Medicinal Chemistry. 29 (9): 1780–3. doi:10.1021/jm00159a037. PMID 2875186.
