Atipamezole
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Clinical data | |
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AHFS/Drugs.com | International Drug Names |
ATCvet code | QV03AB90 (WHO) |
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Identifiers | |
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CAS Number | 104054-27-5 ![]() |
PubChem (CID) | 71310 |
ChemSpider | 64427 ![]() |
UNII | 03N9U5JAF6 ![]() |
KEGG | D03002 ![]() |
ChEMBL | CHEMBL353972 ![]() |
Chemical and physical data | |
Formula | C14H16N2 |
Molar mass | 212.290 g/mol |
3D model (Jmol) | Interactive image |
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Atipamezole (brand name Antisedan, Pfizer) is a synthetic α2 adrenergic receptor antagonist, indicated for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs.[1]
It has also been researched in humans as a potential anti-Parkinsonian drug.[2]
Contents
Dosing[edit]
In a study using New Zealand white rabbits, the optimal dose for revival of sedation by a medetomidine-ketamine mixture was found to be equal to or double the dose of medetomidine.[3]
See also[edit]
- Detomidine, etc.
References[edit]
- ^ Pfizer Animal Health ANTISEDAN Product Overview Archived June 17, 2008, at the Wayback Machine.
- ^ Pertovaara A, Haapalinna A, Sirviö J, Virtanen R (2005). "Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist". CNS Drug Reviews. 11 (3): 273–88. doi:10.1111/j.1527-3458.2005.tb00047.x. PMID 16389294.
- ^ Kim MS; et al. (2004). "Reversal of Medetomidine-Ketamine Combination Anesthesia in Rabbits by Atipamezole". Experimental Animals. 53 (5): 423–428. doi:10.1538/expanim.53.423.
External links[edit]
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