BD1067

BD1067
Identifiers
	IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-N-ethyl-1-pyrrolidineethanamine;
CAS Number	138356-12-4
PubChem (CID)	9796923
ChemSpider	7972689
Chemical and physical data
Formula	C16H24Cl2N2
Molar mass	315.28 g/mol
3D model (Jmol)	Interactive image
	SMILES CCN(CCC1=CC(=C(C=C1)Cl)Cl)CCN2CCCC2 ;
	InChI InChI=1S/C16H24Cl2N2/c1-2-19(11-12-20-8-3-4-9-20)10-7-14-5-6-15(17)16(18)13-14/h5-6,13H,2-4,7-12H2,1H3 ; Key:NMEAEGORKFOIDR-UHFFFAOYSA-N ;

BD1067 or N-[2-(3,4-dichlorophenyl)ethyl]-N-ethyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 2 ± 0.5 nM for the sigma-1 receptor and greater than 19 times selectivity over the sigma-2 receptor.^[1]

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1067 significantly attenuates the behavioral toxicity of cocaine.^[1]

References[edit]

^ ^a ^b Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. doi:10.1016/s0014-2999(00)00917-1.