Setastine
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| CAS Number | 59767-13-4 |
| PubChem (CID) | 43082 |
| ChemSpider | 39258 |
| UNII | 6G3OCF528J  |
| Chemical and physical data | |
| Formula | C22H28ClNO |
| Molar mass | 357.92 g/mol |
| 3D model (Jmol) | Interactive image |
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Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.[1][2]
Pharmacology[edit]
Pharmacodynamics[edit]
Setastine acts as a highly selective H1 receptor antagonist.[3] It has no anticholinergic, antiadrenergic, or antiserotonergic effects.
Pharmacokinetics[edit]
Setastine penetrates the blood-brain-barrier only weakly, hence, it is not sedating or is only mildly so.[3]
See also[edit]
References[edit]
- ^ Lantos A; Tóth A; Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica (English Edition). 39 (1): 22–4. PMID 1677500.
- ^ Hirschberg A; Ribári O; Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica (English Edition). 37 (4): 202–4. PMID 2576575.
- ^ a b Porszász J, Varga F, Porszász KG, et al. (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–5. PMID 1982751.
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