Clobenpropit

Clobenpropit
Clinical data
ATC code	none
Legal status
Legal status	Investigative new drug (not yet approved by the FDA);
Identifiers
	IUPAC name N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine;
CAS Number	145231-45-4
PubChem (CID)	2790
IUPHAR/BPS	1223
ChemSpider	2688
ChEMBL	CHEMBL14690
Chemical and physical data
Formula	C14H17ClN4S
Molar mass	308.83 g/mol
3D model (Jmol)	Interactive image
	SMILES C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl ;

Clobenpropit is a histamine H₃ receptor antagonist.^[1] It has neuroprotective effects via stimulation of GABA release in the brain.^[2]

References[edit]

^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology. 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology. 563 (1-3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.