Acotiamide

Acotiamide

Clinical data
Trade names	Acofide (JP)
Routes of administration	By mouth (tablets)
ATC code	None
Legal status
Legal status	US: Not approved Rx-only (JP)
Pharmacokinetic data
Protein binding	84.21–85.95%
Metabolism	UGT1A8 and 1A9 (major)
Biological half-life	10.9–21.7 hours
Excretion	Feces (92.7%), urine (5.3%)
Identifiers
IUPAC name N-{2-[bis(1-Methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide
CAS Number	185106-16-5 N
PubChem (CID)	5282338
ChemSpider	4445505 Y
UNII	D42OWK5383 Y
KEGG	D08838 N
ChEMBL	CHEMBL2107723 N
Chemical and physical data
Formula	C21H30N4O5S
Molar mass	450.55 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O
InChI InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) Y Key:TWHZNAUBXFZMCA-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Acotiamide (brand name Acofide, codenamed YM-443 and Z-338) is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. It acts as an acetylcholinesterase inhibitor.