Cerlapirdine

Cerlapirdine
Clinical data
ATC code	none;
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name N,N-dimethyl-3-[(3-naphthalen-1-ylsulfonyl-2H-indazol-5-yl)oxy]propan-1-amine;
CAS Number	925448-93-7;
PubChem CID	16071605;
ChemSpider	17231095;
KEGG	D10099 ;
ChEMBL	CHEMBL2103880;
Chemical and physical data
Formula	C22H23N3O3S
Molar mass	409.501 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=S(=O)(c1c2cc(OCCCN(C)C)ccc2nn1)c4c3ccccc3ccc4 ;
	InChI InChI=1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24) ; Key:NXQGEDVQXVTCDA-UHFFFAOYSA-N ;

Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia.^[1] In a phase II clinical trial it demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events,^[2] but no further development has occurred since 2011.^[3]

It exerts its effects by acting as a selective 5-HT₆ receptor antagonist.^[1]

References[edit]

^ ^a ^b Codony X, Vela JM, Ramírez MJ (February 2011). "5-HT(6) receptor and cognition". Current Opinion in Pharmacology. 11 (1): 94–100. doi:10.1016/j.coph.2011.01.004. PMID 21330210.
^ Franco Borsini (2011). International review of neurobiology: Pharmacology of 5-HT6 receptors. Part 2. Academic Press. p. 5. ISBN 978-0-12-385902-0. Retrieved 25 October 2011.
^ Drug Profile: Cerlapirdine

[pmid21330210-1] Codony X, Vela JM, Ramírez MJ (February 2011). "5-HT(6) receptor and cognition". Current Opinion in Pharmacology. 11 (1): 94–100. doi:10.1016/j.coph.2011.01.004. PMID 21330210.

[Borsini2011-2] Franco Borsini (2011). International review of neurobiology: Pharmacology of 5-HT6 receptors. Part 2. Academic Press. p. 5. ISBN 978-0-12-385902-0. Retrieved 25 October 2011.

[3] Drug Profile: Cerlapirdine

[1]

[2]

[3]

v t e Nootropics

Ampakines	CX-516 CX-546 CX-614 Farampator (CX-691) CX-717 IDRA-21 LY-404,187 LY-503,430 Nooglutyl Org 26576 PEPA S-18986

Cholinergics	mAChR agonists: 77-LH-28-1 ADX-47273 Alvameline Arecoline Cevimeline CI-1017 Milameline Sabcomeline Tazomeline Xanomeline nAChR agonists: AR-R17779 Bradanicline Cotinine GTS-21 Ispronicline Nicotine PHA-543,613 PNU-282,987 Pozanicline Rivanicline SIB-1553A SSR-180,711 TC-1827 WAY-317,538 AChE inhibitors: Celastrus paniculatus Cymserine Donepezil Galantamine Huperzine A (Huperzia Serrata) Ladostigil Metrifonate Physostigmine Rivastigmine Tacrine Others: Alpha-GPC Choline Dimethylethanolamine Citicoline

Racetams	Aniracetam Brivaracetam Coluracetam Etiracetam Fasoracetam Levetiracetam Nebracetam Nefiracetam Oxiracetam Phenylpiracetam Piracetam Pramiracetam Rolziracetam Seletracetam

Nutrients	Acetylcarnitine Choline Omega-3 fatty acids Magnesium threonate Phosphatidylserine Pyritinol Sulbutiamine Thiamine

Others	Aceglutamide Adafenoxate Bacopa monnieri BAY 73-6691 Bifemelane Bilobalide (Ginkgo biloba) C16 Carbenoxolone Centella asiatica Cinnarizine Ciproxifan Clitoria ternatea Cyprodenate Dihexa Edaravone Eleutherococcus senticosus Ergoloid Ensaculin Emoxypine Fipexide Ginseng Guarana Idebenone Indeloxazine ISRIB Leteprinim Linopirdine Meclofenoxate (centrophenoxine) Methylene blue Nizofenone Noopept NSI-189 P7C3 Pirisudanol Pitolisant PRL-8-53 Razobazam Rubidium S-17092 Semax Shilajit Suritozole Taltirelin Teniloxazine Tianeptine Tricyanoaminopropene Uncaria tomentosa Vincamine Vinpocetine

v t e Psychoanaleptics: Antidementia agents (N06D)

AChE inhibitors	Donepezil Galantamine Huperzine A (Huperzia serrata) Rivastigmine Tacrine

BACE inhibitors	Lanabecestat Semagacestat Verubecestat

Others	Bifemelane Ergoloid Meclofenoxate (centrophenoxine) Memantine Nicergoline

Cerlapirdine

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References[edit]

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Clinical data

ATC code	none
Legal status
Legal status	Investigational
Identifiers
IUPAC name N,N-dimethyl-3-[(3-naphthalen-1-ylsulfonyl-2H-indazol-5-yl)oxy]propan-1-amine
CAS Number	925448-93-7
PubChem CID	16071605
ChemSpider	17231095
KEGG	D10099^Y
ChEMBL	CHEMBL2103880
Chemical and physical data
Formula	C₂₂H₂₃N₃O₃S
Molar mass	409.501 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(c1c2cc(OCCCN(C)C)ccc2nn1)c4c3ccccc3ccc4
InChI InChI=1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24) Key:NXQGEDVQXVTCDA-UHFFFAOYSA-N