Tolonidine

Tolonidine
Names
	IUPAC name N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
Identifiers
CAS Number	4201-22-3
3D model (Jmol)	Interactive image
ChemSpider	65112
KEGG	D07168
PubChem	72138
UNII	I4O795Q03O
	InChI InChI=1S/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14) Key: KWBTZIFLQYYPTH-UHFFFAOYSA-N ; InChI=1/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14) Key: KWBTZIFLQYYPTH-UHFFFAOYAF ;
	SMILES CC1=CC(=C(C=C1)NC2=NCCN2)Cl ;
Properties
Chemical formula	C10H12ClN3
Molar mass	209.67538
Pharmacology
ATC code	C02AC04 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Tolonidine is an antihypertensive.^[1]^[2]^[3]

References[edit]

^ Cosnier, D.; Duchene-Marullaz, P.; Grimal, J.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate". Arzneimittel-Forschung. 25 (10): 1557–61. PMID 1243037.
^ Cosnier, D.; Labrid, C.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis". Arzneimittel-Forschung. 25 (11): 1802–6. PMID 1243090.
^ Cosnier, D.; Hache, J.; Labrid, C.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity". Arzneimittel-Forschung. 25 (12): 1926–33. PMID 3186.

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