Piperoxan
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| Clinical data | |
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| Routes of administration |
Oral |
| ATC code | none |
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| CAS Number | 59-39-2 135-87-5 (hydrochloride) |
| PubChem (CID) | 6040 |
| ChemSpider | 5817 |
| UNII | 9ZCS27634Y  |
| ChEMBL | CHEMBL31836 |
| Chemical and physical data | |
| Formula | C14H19NO2 |
| Molar mass | 233.31 g/mol |
| 3D model (Jmol) | Interactive image |
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Piperoxan, also known as benodaine, is a drug which was the very first antihistamine to be discovered.[1][2] This compound, derived from benzodioxan, was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.[1][2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.[1][2][3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.[1]
See also[edit]
References[edit]
- ^ a b c d Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.
- ^ a b c Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.
- ^ Fourneau, Ernest; Bovet, Daniel (1933). "Recherches sur l'action sympathicolytique d'un nouveau dérivé du dioxane". Archives Internationales de Pharmacodynamie et de Thérapie. 46: 178–91. ISSN 0003-9780.
- ^ "Daniel Bovet - Biography".
