Pheniprazine

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Pheniprazine
Pheniprazine.png
Clinical data
Routes of
administration		 Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.000.215
Chemical and physical data
Formula C9H14N2
Molar mass 150.22 g/mol
 NYesY (what is this?)  (verify)

Pheniprazine (Catron, Cavodil) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s.[1][2][3] It was also used in the treatment of angina pectoris and schizophrenia.[4][5] Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.[6][7][8]

See also[edit]

References[edit]

  1. ^ LEAR TE, BROWNE MW, GREEVES JA (November 1962). "A controlled trial of cavodil (pheniprazine) in depression". J Ment Sci. 108: 856–58. PMID 13928843. 
  2. ^ Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical pharmacology. 35 (8): 1381–7. doi:10.1016/0006-2952(86)90285-6. PMID 2870717. 
  3. ^ EBERSON LE, PERSSON K (July 1962). "Studies on Monoamine Oxidase Inhibitors. 1. The Autoxidation of beta-Phenylisopropylhydrazine as a Model Reaction for Irreversible Monoamine Oxidase Inhibition.". J Med Pharm Chem. 91: 738–52. PMID 14056405. 
  4. ^ SANDLER G (March 1961). "Clinical evaluation of pheniprazine in angina pectoris". Br Med J. 1 (5228): 792–4. doi:10.1136/bmj.1.5228.792. PMC 1953879Freely accessible. PMID 13746179. 
  5. ^ WICKSTROM L, HAHN N (September 1962). "[beta-Phenylisoprophlhydrazine (Catran) in schizophrenia.]". Nord Med (in Swedish). 68: 1165–7. PMID 14000469. 
  6. ^ FENTEM PH, HOWITT G (December 1961). "Fatal jaundice after administration of pheniprazine". Br Med J. 2 (5267): 1616–7. doi:10.1136/bmj.2.5267.1616. PMC 1970739Freely accessible. PMID 13892290. 
  7. ^ FRANDSEN E (1962). "Toxic amblyopia during antidepressant treatment with pheniprazine (Catran)". Acta Psychiatr Scand. 38: 1–14. doi:10.1111/j.1600-0447.1962.tb01780.x. PMID 13894598. 
  8. ^ THOMSEN NJ (January 1963). "[Optic neuritis after treatment with Catran.]". Ugeskrift for Læger (in Danish). 125: 138–9. PMID 13981222. 


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