Pipoxizine

Pipoxizine
Clinical data
ATC code	None
Identifiers
	IUPAC name 2-(2-{2-[4-(Diphenylmethylene)-1-piperidinyl]ethoxy}ethoxy)ethanol;
CAS Number	55837-21-3
PubChem (CID)	68750
ChemSpider	61995
Chemical and physical data
Formula	C24H31NO3
Molar mass	381.508 g/mol
3D model (Jmol)	Interactive image
	SMILES c1ccc(cc1)C(=C2CCN(CC2)CCOCCOCCO)c3ccccc3 ;
	InChI InChI=1S/C24H31NO3/c26-16-18-28-20-19-27-17-15-25-13-11-23(12-14-25)24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-10,26H,11-20H2 ; Key:SCMPXORBOTWFTI-UHFFFAOYSA-N ;

Pipoxizine (INN) is a first-generation antihistamine as well as serotonin antagonist which is closely related structurally to antihistamines of the diphenylmethane/piperazine family.^[1]^[2] It was investigated as a bronchodilator but was never marketed.^[1]^[3]^[4]

References[edit]

^ ^a ^b C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1619–. ISBN 978-0-412-46630-4.
^ World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O.
^ Brunner A, Gartmann J, Studler H. "Pipoxizine, a New Bronchodilator". Lung. 154 (2): 143.
^ Neukirch F, Korobaeff M, Verdier F, Timsit G, Fay M, Drutel P (1978). "[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine]". Rev Inst Hyg Mines (Hasselt) (in French). 33 (4): 191–5. PMID 45187.

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