Pinacidil
From Wikipedia, the free encyclopedia
Names | |
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IUPAC name
N-cyano-N'-pyridin-4-yl-N''-(1,2,2-trimethylpropyl)guanidine
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Identifiers | |
85371-64-8 | |
3D model (Jmol) | Interactive image |
ChEMBL | ChEMBL1159 ChEMBL1200338 |
ChemSpider | 4660 |
ECHA InfoCard | 100.150.851 |
2412 | |
PubChem | 4826 |
UNII | BB4UGO5K0D |
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Properties | |
C13H19N5 | |
Molar mass | 245.32346 |
Pharmacology | |
C02DG01 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.[1] It reduces blood pressure and peripheral resistance and produces fluid retention.[2]
References[edit]
- ^ Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155.
- ^ Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia (31st ed.). London: Royal Pharmaceutical Society. pp. 2739 pages. ISBN 0-85369-342-0.
External links[edit]
- Pinacidil at the US National Library of Medicine Medical Subject Headings (MeSH)
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