Bay K8644
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Names | |
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IUPAC name
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
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Identifiers | |
71145-03-4 ![]() |
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3D model (Jmol) | Interactive image |
ChEBI | CHEBI:34555 ![]() |
ChEMBL | ChEMBL513599 ![]() |
ChemSpider | 2213 ![]() |
ECHA InfoCard | 100.163.930 |
2511 | |
PubChem | 2303 |
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Properties | |
C16H15F3N2O4 | |
Molar mass | 356.30 g·mol−1 |
Insoluble | |
Solubility in other solvents | DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL |
Hazards | |
EU classification (DSD)
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Xi |
R-phrases | R36/38 |
S-phrases | S26 S36 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Bay K8644 is a chemical compound that functions as a calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
Mechanism of Action[edit]
Bay K8644 targets Voltage-sensitive dihydropyridine (DHP) Calcium Channels (L-Type). It is the first positive inotropic agent shown to act specifically and directly on calcium channels.[3]
References[edit]
- ^ (±)-Bay K8644[permanent dead link] at Sigma-Aldrich
- ^ Bay K8644 at PubChem
- ^ Thomas, G; Chung, M; Cohen, CJ (January 1985). "A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent.". Circ Res. PMID 2578336.
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