Eplivanserin

Eplivanserin
Clinical data
Routes of; administration	Oral
ATC code	none;
Identifiers
	IUPAC name (Z,E)-1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime;
CAS Number	130579-75-8 ;
PubChem CID	5493160;
ChemSpider	13267837 ;
UNII	3CO94WO6DJ;
KEGG	D10006 ;
ECHA InfoCard	100.189.857
Chemical and physical data
Formula	C19H21FN2O2
Molar mass	328.381 g/mol
3D model (Jmol)	Interactive image;
	SMILES c2cc(O)ccc2\C=C\C(=N\OCCN(C)C)\c1ccccc1F ;
	InChI InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,23H,13-14H2,1-2H3/b12-9+,21-19- ; Key:VAIOZOCLKVMIMN-PRJWTAEASA-N ;
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Eplivanserin (SR-46,349; planned trade name Ciltyri) was an experimental drug for the treatment of insomnia which was being developed by Sanofi Aventis.^[1]

Sanofi Aventis announced in December 2009 that it was withdrawing its application for approval of eplivanserin from both the U.S. Food and Drug Administration and the European Medicines Agency.^[2]

Mechanism of action[edit]

Eplivanserin is an inverse agonist on the serotonin receptor subtype 5-HT_2A. In contrast to older sedating drugs acting on 5-HT_2A receptors (e.g., mirtazapine, clozapine, risperidone), eplivanserin has practically no affinity to dopamine, histamine and adrenergic receptors.^[3]

Study results[edit]

In a placebo controlled Phase II clinical trial with 351 subjects, eplivanserin reduced the sleep latency by 39 minutes (versus 26 minutes under placebo).^[3]

References[edit]

^ "Future Treatments for Depression, Anxiety, Sleep Disorders, Psychosis, and ADHD -- Neurotransmitter.net".
^ Spencer, Mimosa; Berton, Elena (21 December 2009). "Sanofi-Aventis Discontinues Eplivanserin For Insomnia". Dow Jones & Co. Archived from the original on 21 July 2011. Retrieved 27 January 2010.
^ ^a ^b Teergarden, BR; Al Shamma, H; Xiong, Y (2008). "5-HT2A Inverse-Agonists for the Treatment of Insomnia". Current Topics in Medicinal Chemistry. 8 (11): 969–976. doi:10.2174/156802608784936700. PMID 18673166.

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[urlFuture_Treatments_for_Depression.2C_Anxiety.2C_Sleep_Disorders.2C_Psychosis.2C_and_ADHD_--_Neurotransmitter.net-1] "Future Treatments for Depression, Anxiety, Sleep Disorders, Psychosis, and ADHD -- Neurotransmitter.net".

[2] Spencer, Mimosa; Berton, Elena (21 December 2009). "Sanofi-Aventis Discontinues Eplivanserin For Insomnia". Dow Jones & Co. Archived from the original on 21 July 2011. Retrieved 27 January 2010.

[Teergarden-3] Teergarden, BR; Al Shamma, H; Xiong, Y (2008). "5-HT2A Inverse-Agonists for the Treatment of Insomnia". Current Topics in Medicinal Chemistry. 8 (11): 969–976. doi:10.2174/156802608784936700. PMID 18673166.

[1]

[2]

[3]

Eplivanserin

Contents

Mechanism of action[edit]

Study results[edit]

See also[edit]

References[edit]

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Clinical data

Routes of administration	Oral
ATC code	none
Identifiers
IUPAC name (Z,E)-1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime
CAS Number	130579-75-8^Y
PubChem CID	5493160
ChemSpider	13267837^N
UNII	3CO94WO6DJ
KEGG	D10006^N
ECHA InfoCard	100.189.857
Chemical and physical data
Formula	C₁₉H₂₁FN₂O₂
Molar mass	328.381 g/mol
3D model (Jmol)	Interactive image
SMILES c2cc(O)ccc2\C=C\C(=N\OCCN(C)C)\c1ccccc1F
InChI InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,23H,13-14H2,1-2H3/b12-9+,21-19-^N Key:VAIOZOCLKVMIMN-PRJWTAEASA-N^N
^NY (what is this?) (verify)