BHF-177
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Identifiers | |
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CAS Number | 917896-43-6 ![]() |
IUPHAR/BPS | 5503 |
ChemSpider | 26286940 ![]() |
Chemical and physical data | |
Formula | C19H20F3N3 |
Molar mass | 347.377 g/mol |
3D model (Jmol) | Interactive image |
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BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It was shown to reduce self-administration of nicotine in animal studies.[2]
References[edit]
- ^ Guery, S; Floersheim, P; Kaupmann, K; Froestl, W (2007). "Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors". Bioorganic & Medicinal Chemistry Letters. 17 (22): 6206–11. doi:10.1016/j.bmcl.2007.09.023. PMC 2278029
. PMID 17884493.
- ^ Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (2008). "Positive Modulation of GABAB Receptors Decreased Nicotine Self-administration and Counteracted Nicotine-induced Enhancement of Brain Reward Function in Rats". J. Pharmacol. Exp. Ther. 326 (1): 306–14. doi:10.1124/jpet.108.139204. PMC 2574924
. PMID 18445779.
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