PNU-142633

PNU-142633
Names
	IUPAC name (S)-1-(2-(4-(4-Carbamoylphenyl)piperazin-1-yl)ethyl)-N-methylisochroman-6-carboxamide
	Other names PNU-142633F
Identifiers
CAS Number	187665-65-2 ; 249765-69-3 (maleate) ;
3D model (Jmol)	Interactive image;
ChemSpider	8020862;
PubChem CID	9845148;
	InChI InChI=1S/C24H30N4O3/c1-26-24(30)19-4-7-21-18(16-19)9-15-31-22(21)8-10-27-11-13-28(14-12-27)20-5-2-17(3-6-20)23(25)29/h2-7,16,22H,8-15H2,1H3,(H2,25,29)(H,26,30)/t22-/m0/s1 Key: PNTVCCRNJOGKGA-QFIPXVFZSA-N ; InChI=1/C24H30N4O3/c1-26-24(30)19-4-7-21-18(16-19)9-15-31-22(21)8-10-27-11-13-28(14-12-27)20-5-2-17(3-6-20)23(25)29/h2-7,16,22H,8-15H2,1H3,(H2,25,29)(H,26,30)/t22-/m0/s1 Key: PNTVCCRNJOGKGA-QFIPXVFZBB ;
	SMILES NC(C(C=C1)=CC=C1N2CCN(CC[C@@H]3OCCC4=C3C=CC(C(NC)=O)=C4)CC2)=O ;
Properties
Chemical formula	C24H30N4O3
Molar mass	422.53 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

PNU-142633 is an experimental drug candidate for the treatment of migraine. It exerts its effect as a selective, high affinity 5-HT1D receptor antagonist.^[1]^[2] PNU-142633 is well tolerated after oral administration.^[3]

References[edit]

^ Pregenzer, JF; Alberts, GL; Im, WB; Slightom, JL; Ennis, MD; Hoffman, RL; Ghazal, NB; Tenbrink, RE (1999). "Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)". British journal of pharmacology. 127 (2): 468–72. doi:10.1038/sj.bjp.0702532. PMC 1566017. PMID 10385247.
^ PNU 142633, Santa Cruz Biotechnology
^ Fleishaker, JC; Pearson, LK; Knuth, DW; Gomez-Mancilla, B; Francom, SF; McIntosh, MJ; Freestone, S; Azie, NE (1999). "Pharmacokinetics and tolerability of a novel 5-HT1D agonist, PNU-142633F". International journal of clinical pharmacology and therapeutics. 37 (10): 487–92. PMID 10543315.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[1] Pregenzer, JF; Alberts, GL; Im, WB; Slightom, JL; Ennis, MD; Hoffman, RL; Ghazal, NB; Tenbrink, RE (1999). "Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)". British journal of pharmacology. 127 (2): 468–72. doi:10.1038/sj.bjp.0702532. PMC 1566017. PMID 10385247.

[2] PNU 142633, Santa Cruz Biotechnology

[3] Fleishaker, JC; Pearson, LK; Knuth, DW; Gomez-Mancilla, B; Francom, SF; McIntosh, MJ; Freestone, S; Azie, NE (1999). "Pharmacokinetics and tolerability of a novel 5-HT1D agonist, PNU-142633F". International journal of clinical pharmacology and therapeutics. 37 (10): 487–92. PMID 10543315.

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[2]

[3]

PNU-142633

References[edit]

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