Dopastin
From Wikipedia, the free encyclopedia
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Names | |
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Systematic IUPAC name
(2E)-N-{(2S)-2-[Hydroxy(nitroso)amino]-3-methylbutyl}-2-butenamide
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Identifiers | |
37134-80-8 | |
3D model (Jmol) | Interactive image |
ChemSpider | 4939169 |
PubChem | 6434226 |
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Properties | |
C9H17N3O3 | |
Molar mass | 215.25 g·mol−1 |
Melting point | 116 to 119 °C (241 to 246 °F; 389 to 392 K)[1] |
Acidity (pKa) | 5.1[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125.[2] It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.[3]
Dopastin can be prepared synthetically from L-valinol.[4]
References[edit]
- ^ a b Merck Index, 11th Edition, 3417
- ^ Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). "Dopastin, an inhibitor of dopamine -hydroxylase". The Journal of antibiotics. 25 (8): 497–500. doi:10.7164/antibiotics.25.497. PMID 4648494.
- ^ H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). "Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase". Agric. Biol. Chem. 38 (11): 2107–2111. doi:10.1271/bbb1961.38.2107.
- ^ Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). "Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin". Journal of the Chemical Society, Chemical Communications (4): 147. doi:10.1039/C39730000147.