NEFA (drug)

NEFA
Identifiers
	IUPAC name (4aR,9aS)-N-Ethyl-4,4a,9,9a-tetrahydro-1H-fluoren-4a-amine;
PubChem (CID)	57426056
Chemical and physical data
Formula	C15H19N
Molar mass	213.3181 g/mol
3D model (Jmol)	Interactive image
	SMILES CCNC12CC=CCC1CC3=CC=CC=C23 ;
	InChI InChI=1S/C15H19N/c1-2-16-15-10-6-5-8-13(15)11-12-7-3-4-9-14(12)15/h3-7,9,13,16H,2,8,10-11H2,1H3/t13-,15+/m0/s1 ; Key:DRCWOKJLSQUJPZ-DZGCQCFKSA-N ;
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NEFA is a moderate affinity NMDA antagonist (IC₅₀ = 0.51 μM). It is a structural analog of phencyclidine.^[1] It was first synthesized by a team at Parke Davis in the late 1950s.^[2]

References[edit]

^ Dilmore JG, Johnson JW (1998). "Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine". Biophysical Journal. 75 (4): 1801–16. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852. PMID 9746522.
^ GB Patent 893920 - Polycyclic amino compounds and methods for their production

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