Distigmine
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(Redirected from Distigmine bromide)
Distigmine bromide
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| Clinical data | |
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| Routes of administration |
oral, i.m. |
| ATC code | N07AA03 (WHO) |
| Pharmacokinetic data | |
| Bioavailability | 4.65% [1] |
| Biological half-life | 65 h [1] |
| Excretion | renal [1] |
| Identifiers | |
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| CAS Number | 15876-67-2  |
| PubChem (CID) | 27522 |
| ChemSpider | 25613 |
| UNII | T940307O7B |
| KEGG | D01228  |
| ChEMBL | CHEMBL1098285 |
| ECHA InfoCard | 100.036.360 |
| Chemical and physical data | |
| Formula | C22H32Br2N4O4 |
| Molar mass | 576.322 g/mol |
| 3D model (Jmol) | Interactive image |
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Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.
References[edit]
- ^ a b c The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.
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