Dimetindene

Dimetindene
Clinical data
Trade names	Fenistil
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, topical
ATC code	D04AA13 (WHO) R06AB03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only);
Identifiers
	IUPAC name (RS)-dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine;
CAS Number	5636-83-9 3614-69-5
PubChem (CID)	21855
DrugBank	DB08801
ChemSpider	20541
UNII	661FH77Z3P
KEGG	D07853
ChEMBL	CHEMBL22108
ECHA InfoCard	100.024.622
Chemical and physical data
Formula	C20H24N2
Molar mass	292.418 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
	SMILES n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C ;
	InChI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 ; Key:MVMQESMQSYOVGV-UHFFFAOYSA-N ;
(verify)

Dimetindene^[1] (trade name Fenistil; other name dimethindene maleate) is an antiallergic drug. Dimetindene is an antihistamine/anticholinergic that is a selective H1 antagonist.^[2] As dimetindene only minimally passes across the blood-brain barrier,^[3] it is classified as a second generation antihistamine.

Clinical use[edit]

Dimetindene is used orally and topically as an antipruritic.^[4] It is used topically to treat skin irritations, such as insect bites. Dimentidene is also administered orally to treat allergies, such as hay fever. Unlike first generation antihistamines, it causes only minimal drowsiness.

References[edit]

^ https://www.wikigenes.org/e/chem/e/21855.html
^ https://www.drugs.com/international/dimetindene.html
^ https://www.wikigenes.org/e/ref/e/1353628.html
^ Wexler, L. (1962). "A Clinical Evaluation of Dimethindene". Current Therapeutic Research, Clinical and Experimental. 4: 306–9. PMID 14006402.

[1] ttps://www.wikigenes.org/e/chem/e/21855.html

[2] ttps://www.drugs.com/international/dimetindene.html

[3] ttps://www.wikigenes.org/e/ref/e/1353628.html

[4] Wexler, L. (1962). "A Clinical Evaluation of Dimethindene". Current Therapeutic Research, Clinical and Experimental. 4: 306–9. PMID 14006402.

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v t e Antipruritics (D04)

Antihistamines for topical use	Thonzylamine Mepyramine Thenalidine Tripelennamine Chloropyramine Promethazine Tolpropamine Dimetindene Clemastine Bamipine Isothipendyl Diphenhydramine Chlorphenoxamine

Anesthetics for topical use	Lidocaine Dibucaine Oxybuprocaine Benzocaine Quinisocaine Tetracaine Pramocaine

Others	Corticosteroids (e.g., hydrocortisone) Counterirritants (e.g., mint oil, menthol, camphor) Nalfurafine

v t e Antihistamines (R06)

Aminoalkyl ethers	Bromazine (bromodiphenhydramine) Carbinoxamine Clemastine Chlorphenoxamine Diphenylpyraline Diphenhydramine Doxylamine Orphenadrine Phenyltoloxamine

Substituted alkylamines	Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Dimetindene Pheniramine Talastine

Substituted ethylenediamines	Chloropyramine Histapyrrodine Mepyramine Methapyrilene Tripelennamine (pyribenzamine)

Phenothiazine derivatives	Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine

Piperazine derivatives	Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Hydroxyzine Meclizine Oxatomide

Others for systemic use	Antazoline Azanator Azatadine Bamipine Cyproheptadine Deptropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Mebhydrolin Mizolastine Olopatadine Phenindamine Pimethixene Pyrrobutamine Quifenadine Rupatadine Triprolidine selective (Acrivastine Astemizole Azelastine Bilastine Desloratadine Fexofenadine Loratadine Terfenadine)

For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Isothipendyl Mepyramine Promethazine Thenalidine

Dimetindene

Clinical use[edit]

References[edit]

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