WAY-208,466

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WAY-208,466
Skeletal formula of WAY-208,466
Space-filling model of the WAY-208,466 molecule
ATC code none
Identifiers
'Systematic (IUPAC) name: N-[(2Z)-4-(2,4-dichlorophenyl)-3-(2-methylpropyl)-1,3-thiazol-2(3H)-ylidene]-2-(pyrazin-2-yloxy)acetohydrazide
CAS Number ?
PubChem (CID) 11820788
ChemSpider 9995440
ChEMBL CHEMBL571858
Chemical and physical data
Formula C19H19Cl2N5O2S
Molar mass 452.36 g/mol
3D model (Jmol) Interactive image

WAY-208,466 is a potent and highly selective full agonist of the 5-HT6 receptor.[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.[1] Animal studies have shown that WAY-208,466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.[1][2]

See also[edit]

References[edit]

  1. ^ a b c Schechter LE, Lin Q, Smith DL, et al. (May 2008). "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology. 33 (6): 1323–35. doi:10.1038/sj.npp.1301503. PMID 17625499. 
  2. ^ Carr GV, Schechter LE, Lucki I (March 2010). "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology. 213 (2–3): 499–507. doi:10.1007/s00213-010-1798-7. PMC 2910165Freely accessible. PMID 20217056. 
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