Ramosetron

Ramosetron
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (ODT), IV
ATC code	None;
Pharmacokinetic data
Biological half-life	5.8 hours
Identifiers
	IUPAC name (1-Methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]methanone;
CAS Number	132907-72-3 ;
PubChem CID	108000;
IUPHAR/BPS	2301; [3H]ramosetron: 2305;
ChemSpider	97112 ;
UNII	7ZRO0SC54Y;
KEGG	D02016 ;
ChEMBL	CHEMBL1643895 ;
ECHA InfoCard	100.217.075
Chemical and physical data
Formula	C17H17N3O
Molar mass	279.33 g/mol
3D model (Jmol)	Interactive image;
	SMILES CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4 ;
	InChI InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1 ; Key:NTHPAPBPFQJABD-LLVKDONJSA-N ;
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Ramosetron (INN) is a serotonin 5-HT₃ receptor antagonist for the treatment of nausea and vomiting.^[1] Ramosetron is also indicated for a treatment of "diarrhea-predominant irritable bowel syndrome in males".^[2] In India it is marketed under the brand name of IBset.

It is only licensed for use in Japan and selected Southeast Asian countries. In Japan it is sold under the trade name Iribo.^[3] Elsewhere it is commonly sold under the trade name Nasea and in India as Nozia (150 μg/mL injection & 100 μg oral tablet).^[4]

References[edit]

^ Fujii Y, Saitoh Y, Tanaka H, Toyooka H (February 2000). "Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery". Anesth. Analg. 90 (2): 472–5. doi:10.1097/00000539-200002000-00043. PMID 10648342.
^ http://www.astellas.com/en/corporate/news/detail/astellas-launches-irribow-for.html
^ Summary in Japanese. Retrieved on September 4, 2012.
^ Abridged prescribing information — Nasea (MIMS Philippines). Retrieved on June 13, 2008.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

[1] Fujii Y, Saitoh Y, Tanaka H, Toyooka H (February 2000). "Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery". Anesth. Analg. 90 (2): 472–5. doi:10.1097/00000539-200002000-00043. PMID 10648342.

[2] ttp://www.astellas.com/en/corporate/news/detail/astellas-launches-irribow-for.html

[3] Summary in Japanese. Retrieved on September 4, 2012.

[4] Abridged prescribing information — Nasea (MIMS Philippines). Retrieved on June 13, 2008.

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v t e Antiemetics (A04)

5-HT₃ serotonin ion channel antagonists	Alosetron Azasetron Bemesetron Cilansetron Clozapine Dazopride Dolasetron Granisetron Lerisetron Metoclopramide Mianserin Mirtazapine Olanzapine Ondansetron Palonosetron (+netupitant) Quetiapine Ramosetron Ricasetron Tropisetron Zatosetron

5-HT serotonin G-protein receptor antagonists	Clozapine Cyproheptadine Hydroxyzine Olanzapine Risperidone Ziprasidone

CB₁ agonists (cannabinoids)	Dronabinol Nabilone Tetrahydrocannabinol (cannabis)

D₂/D₃ antagonists	Alizapride Bromopride Chlorpromazine Clebopride Domperidone Haloperidol Hydroxyzine Itopride Metoclopramide Metopimazine Prochlorperazine Thiethylperazine Trimethobenzamide

H₁ antagonists (antihistamines)	Cyclizine Dimenhydrinate Diphenhydramine Hydroxyzine Meclizine Promethazine

mACh antagonists (anticholinergics)	Atropine Diphenhydramine Hydroxyzine (very mild) Hyoscyamine Scopolamine

NK₁ antagonists	Aprepitant Casopitant Ezlopitant Fosaprepitant Maropitant Netupitant Rolapitant Vestipitant

Others	Cerium oxalate Dexamethasone Lorazepam Midazolam Propofol

Ramosetron

References[edit]

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Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth (ODT), IV
ATC code	None
Pharmacokinetic data
Biological half-life	5.8 hours
Identifiers
IUPAC name (1-Methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]methanone
CAS Number	132907-72-3^Y
PubChem CID	108000
IUPHAR/BPS	2301 [³H]ramosetron: 2305
ChemSpider	97112^N
UNII	7ZRO0SC54Y
KEGG	D02016^N
ChEMBL	CHEMBL1643895^N
ECHA InfoCard	100.217.075
Chemical and physical data
Formula	C₁₇H₁₇N₃O
Molar mass	279.33 g/mol
3D model (Jmol)	Interactive image
SMILES CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4
InChI InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1^N Key:NTHPAPBPFQJABD-LLVKDONJSA-N^N
^NY (what is this?) (verify)