Quifenadine

Quifenadine
Clinical data
Trade names	Fencarol
Routes of; administration	Oral (tablets), IM injection
ATC code	R06AX31 (WHO)
Legal status
Legal status	OTC (tablets), ℞-only (solution for IM injection) (RU);
Pharmacokinetic data
Bioavailability	45% (Tmax = 1 hour)
Metabolism	Liver
Identifiers
	IUPAC name 1-Azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol;
Synonyms	3-Quinuclidinyldiphenylmethanol
CAS Number	10447-38-8
PubChem (CID)	65600
ChemSpider	59041
UNII	W9A18RJ49B
KEGG	D10230
ChEMBL	CHEMBL1187694
Chemical and physical data
Formula	C20H23NO
Molar mass	293.40 g/mol
3D model (Jmol)	Interactive image
	SMILES OC(c1ccccc1)(c2ccccc2)C4C3CCN(CC3)C4 ;
	InChI InChI=1S/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21/h1-10,16,19,22H,11-15H2 ; Key:PZMAHNDJABQWGS-UHFFFAOYSA-N ;

Quifenadine (Russian: хифенадин, trade name: Phencarol, Фенкарол) is an 2nd generation antihistamine drug, marketed mainly in post-Soviet countries.^[2]^[3] Chemically, it is a quinuclidine derivative.

Indications[edit]

^ ^a ^b "Fencarol (quifenadine) Tablets, for Oral Use. Full Prescribing Information". State Register of Medicines (in Russian). Retrieved 4 January 2016.
^ "Quifenadine". Drugs.com. Retrieved 28 January 2014.
^ Makarov, L.; Balykova, L.; Soldatova, O.; Komolyatova, V.; Serebruany, V. (2010). "The antiarrhythmic properties of quifenadine, H1-histamine receptor blocker in children with premature beats: A randomized controlled pilot trial". American journal of therapeutics. 17 (4): 396–401. doi:10.1097/MJT.0b013e3181a86987. PMID 19487925.

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v t e Antihistamines (R06)

Aminoalkyl ethers	Bromazine (bromodiphenhydramine) Carbinoxamine Clemastine Chlorphenoxamine Diphenylpyraline Diphenhydramine Doxylamine Orphenadrine Phenyltoloxamine

Substituted alkylamines	Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Dimetindene Pheniramine Talastine

Substituted ethylenediamines	Chloropyramine Histapyrrodine Mepyramine Methapyrilene Tripelennamine (pyribenzamine)

Phenothiazine derivatives	Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine

Piperazine derivatives	Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Hydroxyzine Meclizine Oxatomide

Others for systemic use	Antazoline Azanator Azatadine Bamipine Cyproheptadine Deptropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Mebhydrolin Mizolastine Olopatadine Phenindamine Pimethixene Pyrrobutamine Quifenadine Rupatadine Triprolidine selective (Acrivastine Astemizole Azelastine Bilastine Desloratadine Fexofenadine Loratadine Terfenadine)

For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Isothipendyl Mepyramine Promethazine Thenalidine

Clinical data

Trade names	Fencarol
Routes of administration	Oral (tablets), IM injection
ATC code	R06AX31 (WHO)
Legal status
Legal status	OTC (tablets), ℞-only (solution for IM injection) (RU)
Pharmacokinetic data
Bioavailability	45% (T_max = 1 hour)^[1]
Metabolism	Liver
Identifiers
IUPAC name 1-Azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol
Synonyms	3-Quinuclidinyldiphenylmethanol
CAS Number	10447-38-8
PubChem (CID)	65600
ChemSpider	59041
UNII	W9A18RJ49B^Y
KEGG	D10230
ChEMBL	CHEMBL1187694
Chemical and physical data
Formula	C₂₀H₂₃NO
Molar mass	293.40 g/mol
3D model (Jmol)	Interactive image
SMILES OC(c1ccccc1)(c2ccccc2)C4C3CCN(CC3)C4
InChI InChI=1S/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21/h1-10,16,19,22H,11-15H2 Key:PZMAHNDJABQWGS-UHFFFAOYSA-N