Bromazine

Bromazine
Clinical data
MedlinePlus	a682065
Routes of; administration	Oral
ATC code	R06AA01 (WHO)
Pharmacokinetic data
Bioavailability	High
Protein binding	96%
Metabolism	Mostly hepatic (CYP-mediated), also renal
Biological half-life	1 to 4 hours
Identifiers
	IUPAC name 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine;
CAS Number	1808-12-4 1808-12-4
PubChem (CID)	2444
IUPHAR/BPS	7132
DrugBank	DB01237
ChemSpider	2350
UNII	202J683U97
ChEBI	CHEBI:59177
ChEMBL	CHEMBL1201245
ECHA InfoCard	100.003.854
Chemical and physical data
Formula	C17H20BrNO
Molar mass	334.251 g/mol
3D model (Jmol)	Interactive image
	SMILES Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2 ;
	InChI InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 ; Key:NUNIWXHYABYXKF-UHFFFAOYSA-N ;
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Bromazine (trade names Ambrodyl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic.^[1] It is a halogenated form of diphenhydramine and in many respects is somewhat stronger than the parent compound. The other three halogenated diphenhydramine derivatives are used in research and chlorodiphenhydramine is also marketed with iododiphenhydramine being a much less common pharmaceutical.

References[edit]

^ MacLaren, W. R.; Bruff, W. C.; Eisenberg, B. C.; Weiner, H.; Martin, W. H. (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of allergy. 13 (3): 307–312. PMID 14377226.

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[1] MacLaren, W. R.; Bruff, W. C.; Eisenberg, B. C.; Weiner, H.; Martin, W. H. (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of allergy. 13 (3): 307–312. PMID 14377226.

[1]

v t e Antihistamines (R06)

Aminoalkyl ethers	Bromazine (bromodiphenhydramine) Carbinoxamine Clemastine Chlorphenoxamine Diphenylpyraline Diphenhydramine Doxylamine Orphenadrine Phenyltoloxamine

Substituted alkylamines	Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Dimetindene Pheniramine Talastine

Substituted ethylenediamines	Chloropyramine Histapyrrodine Mepyramine Methapyrilene Tripelennamine (pyribenzamine)

Phenothiazine derivatives	Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine

Piperazine derivatives	Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Hydroxyzine Meclizine Oxatomide

Others for systemic use	Antazoline Azanator Azatadine Bamipine Cyproheptadine Deptropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Mebhydrolin Mizolastine Olopatadine Phenindamine Pimethixene Pyrrobutamine Quifenadine Rupatadine Triprolidine selective (Acrivastine Astemizole Azelastine Bilastine Desloratadine Fexofenadine Loratadine Terfenadine)

For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Isothipendyl Mepyramine Promethazine Thenalidine

Bromazine

References[edit]

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Clinical data

MedlinePlus	a682065
Routes of administration	Oral
ATC code	R06AA01 (WHO)
Pharmacokinetic data
Bioavailability	High
Protein binding	96%
Metabolism	Mostly hepatic (CYP-mediated), also renal
Biological half-life	1 to 4 hours
Identifiers
IUPAC name 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
CAS Number	1808-12-4^Y 1808-12-4
PubChem (CID)	2444
IUPHAR/BPS	7132
DrugBank	DB01237^Y
ChemSpider	2350^Y
UNII	202J683U97^Y
ChEBI	CHEBI:59177^Y
ChEMBL	CHEMBL1201245^N
ECHA InfoCard	100.003.854
Chemical and physical data
Formula	C₁₇H₂₀BrNO
Molar mass	334.251 g/mol
3D model (Jmol)	Interactive image
SMILES Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2
InChI InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3^Y Key:NUNIWXHYABYXKF-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)