Tynorphin
From Wikipedia, the free encyclopedia
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This article relies largely or entirely upon a single source. (November 2014) |
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| Systematic (IUPAC) name | |
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(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoic acid
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| ATC code | None |
| PubChem | CID 9961318 |
| ChemSpider | 8136925 |
| Chemical data | |
| Formula | C35H46N6O7 |
| Molar mass | 662.8 g/mol |
| 3D model (Jmol) | Interactive image |
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Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.[1] It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.[1] It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp.
Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.[1]
See also[edit]
References[edit]
- ^ a b c Yamamoto Y, Hashimoto J, Shimamura M, Yamaguchi T, Hazato T (April 2000). "Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII". Peptides. 21 (4): 503–8. doi:10.1016/S0196-9781(00)00174-1. PMID 10822105.
