Triprolidine
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Clinical data | |
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Trade names | Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin) |
AHFS/Drugs.com | Monograph |
Pregnancy category |
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Routes of administration |
Oral |
ATC code | R06AX07 (WHO) |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 4% oral |
Protein binding | 90% |
Metabolism | Hepatic (CYP2D6) |
Biological half-life | 4-6 hours |
Excretion | Renal |
Identifiers | |
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CAS Number | 486-12-4 Y |
PubChem (CID) | 5282443 |
IUPHAR/BPS | 1228 |
DrugBank | DB00427 Y |
ChemSpider | 4445597 Y |
UNII | 2L8T9S52QM Y |
KEGG | D01782 N |
ChEBI | CHEBI:84116 N |
ChEMBL | CHEMBL855 Y |
ECHA InfoCard | 100.006.934 |
Chemical and physical data | |
Formula | C19H22N2 |
Molar mass | 278.391 g/mol |
3D model (Jmol) | Interactive image |
Melting point | 60 °C (140 °F) |
Solubility in water | 500 mg/mL (20 °C) |
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NY (what is this?) (verify) |
Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] Like many antihistamines, the most common side effect is drowsiness.[1] Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15–30 minutes.[citation needed]
References[edit]
- ^ a b Goldsmith, P.; Dowd, P. M. (1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic clinics. 11 (1): 87–95. PMID 8094649.
- ^ Williams, B. O.; Liao, S. H.; Lai, A. A.; Arnold, J. D.; Perkins, J. G.; Blum, M. R.; Findlay, J. W. (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical pharmacy. 3 (6): 638–643. PMID 6509877.
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