Licarbazepine
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Top: (R)-(−)-licarbazepine
Bottom: (S)-(+)-licarbazepine |
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| Clinical data | |
|---|---|
| ATC code | None |
| Pharmacokinetic data | |
| Protein binding | <40% |
| Metabolites | Glucuronides |
| Excretion | Mainly renal |
| Identifiers | |
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| CAS Number | 29331-92-8 |
| PubChem (CID) | 114709 |
| ChemSpider | 102704 |
| UNII | XFX1A5KJ3V  |
| KEGG | D09215 |
| ChEMBL | CHEMBL1067 |
| ECHA InfoCard | 100.122.427 |
| Chemical and physical data | |
| Formula | C15H14N2O2 |
| Molar mass | 254.28 g/mol |
| 3D model (Jmol) | Interactive image |
| Chirality | Racemic mixture |
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Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.[1] It is an active metabolite of oxcarbazepine.[1][2] In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]
References[edit]
- ^ a b c d Singh RP, Asconapé JJ (2011). "A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy". J Cent Nerv Syst Dis. 3: 179–87. doi:10.4137/JCNSD.S4888. PMC 3663619
. PMID 23861647. - ^ a b c Bialer M, Soares-da-Silva P (June 2012). "Pharmacokinetics and drug interactions of eslicarbazepine acetate". Epilepsia. 53 (6): 935–46. doi:10.1111/j.1528-1167.2012.03519.x. PMID 22612290.
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