Iodocyanopindolol

Iodocyanopindolol
Clinical data
ATC code	none
Identifiers
	IUPAC name (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile;
CAS Number	85124-14-7
ChEBI	CHEBI:73370
Chemical and physical data
Formula	C16H20IN3O2
Molar mass	413.25 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
	SMILES IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21 ;
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Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β₁ adrenoreceptor antagonist and a 5-HT_1A receptor antagonist. Its ¹²⁵I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.^[1]

References[edit]

^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1983). "Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding". Circulation Research. 53 (6): 752–758. doi:10.1161/01.res.53.6.752. PMID 6139182.

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v t e Beta blockers (C07)

β, non-selective	Alprenolol Bopindolol Bupranolol Carteolol Cloranolol Mepindolol Nadolol Oxprenolol Penbutolol Pindolol/Iodopindolol Propranolol Sotalol Tertatolol Timolol

β₁-selective	Acebutolol Atenolol Betaxolol Bevantolol Bisoprolol Celiprolol Epanolol Esmolol Landiolol Metoprolol Nebivolol Practolol S-Atenolol Talinolol

β₂-selective	Butaxamine

α₁- + β-selective	Arotinolol Carvedilol Labetalol

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III